异博定等药物对人卵巢癌耐药细胞系多药耐受的逆转作用  

Several Drugs Reversing VCR Resistance in Human Ovarian Cancer Cell Line

作　　者：唐东平[1] 李力[1] 黄薇 黎丹戎 陈心秋 

机构地区：[1]广西医科大学附属肿瘤医院

出　　处：《实用癌症杂志》1999年第3期191-193,共3页The Practical Journal of Cancer

基　　金：广西壮族自治区卫生厅科研基金

摘　　要：用已建立的耐长春新碱人卵巢癌的耐药细胞做实验，应用ＭＴＴ法证实：异博定、潘生丁、黄体酮、环孢菌素Ａ和他莫西芬等药，能不同程度的逆转耐药细胞对长春新碱的耐受；高效液相色谱仪测定进一步证实了上述逆转药可保持或增加耐药细胞内长春新碱的药物浓度。该作用系由于逆转药使耐药细胞表达的大量Ｐ糖蛋白功能失活，通过增加细胞摄取药物量或延长药物在细胞内滞留时间形成的。The reversional effect of Isoptin et al drugs to VCR resistance in A2780/VCR human ovarian cancer cell line was studied by MTT method and high performance liquid chromatography(HPLC).Results showed that these drugs can decrease the resistance of A2780/VCR to VCR and maintain or increase the concentration of VCR in A2780/VCR.The reversion mechanism of these drugs may be inaction of P glycoprotein expressed by A2780/VCR,promotion of cell intaking VCR or prolongation of the reserve time of VCR in cells.

关 键 词：多药耐受 卵巢癌 异搏定 药物疗法 

分 类 号：R737.310.5[医药卫生—肿瘤]