载脂蛋白-B基因多态性与胆固醇结石病关系的研究  

Association of polymorphisms of apolipoprotein B gene with cholesterol gallstone disease

作　　者：所广军[1] 韩天权[2] 奉典旭[2] 姜志宏[2] 张圣道[2] 

机构地区：[1]上海东方医院外科 [2]上海第二医科大学附属瑞金医院,上海消化外科研究所200025

出　　处：《中华医学杂志》1999年第9期673-675,共3页National Medical Journal of China

基　　金：上海市科技发展基金!95 41190 2 7

摘　　要：目的　探讨载脂蛋白B(apoB)基因多态位点Ins/De1、XbaI基因多态性与胆固醇结石病的关系。方法　应用聚合酶链反应法和限制性片段长度多肽法 ,观察这两个多态位点在 10 1例胆固醇结石患者和 5 0例对照者的分布。结果　结石组XbaI多态位点的X+等位基因频率显著高于对照组( χ2 =4 0 5P <0 0 5 ) ;X+X-基因型分布也显著高于对照组 ( χ2 =4 5 0P <0 0 5 )。结石组Ins/Del多态位点等位基因出现频率及基因型分布与对照组均无差别。结论　apoB基因XbaI多态位点基因多态性与胆固醇结石病有关 ;未发现Ins/Del多态位点基因多态性与胆固醇结石病有关。Objective To investigate the association between the apolipoprotein B (apoB) gene po1ymorphic sites Ins/De1 and Xbal, and cholesterol gallstone disease Methods The two polymorphic sites of apoB gene were examed in 101 cholesterol gallstone patients and 50 controls by polymerase chain reaction and restriction fragment length polymorphism methods. Results For Xbal polymorphic site, the frequency of the rare allele X + and the distribution of X +X - genotype were significantly higher in the patient group than in the control group ( P < 0 05) For Ins/Del polymorphic site, no significant difference was found in allele frequency and genotype distribution between the patient group and the control group Conclusions Xba1 polymorphism of apoB gene may be associated with cholesterol gallstone disease The association, however, is not present for Ins/De1 polymorphism of apoB gene with cholesterolg allstone disease

关 键 词：载脂蛋白B 胆结石 基因多态性 胆固醇 

分 类 号：R575.620.2[医药卫生—消化系统]