STAT3在宫颈鳞状上皮病变组织中的表达及意义  

STAT3 expression in cervical squamous intraepithelial lesions and its significance

作　　者：陈英[1,2] 范怡冰 

机构地区：[1]扬州大学第五临床医学院 [2]常熟市第二人民医院妇产科,常熟215500

出　　处：《中国优生与遗传杂志》2011年第1期29-30,18,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨信号转录和转录活化因子3(Signal transducer and activator transcription3,STAT3)在宫颈鳞状上皮病变组织中的表达及意义。方法采用RT-PCR方法检测13例宫颈炎组织、12例宫颈上皮内瘤变(Cervical intraepithelialneoplasia,CIN)Ⅰ级、17例CINⅡ-Ⅲ级及33例宫颈鳞状上皮细胞癌(squamous cell carcinoma,SCC)组织中STAT3mR-NA表达.结果 STAT3的表达与宫颈上皮病变的级别和临床分期无关(P均>0.10),与病理分级呈正相关(r=0.52,P<0.05),有脉管浸润和淋巴结转移组及浸润深度>3mm组显著高于无脉管浸润和淋巴结转移组及浸润深度≤3mm组,(P均<0.05);Cox回归分析结果显示STAT3的表达与宫颈癌的不良预后无关。结论 STAT3不能直接促进SCC的发生、发展,但对SCC的浸润、转移、分化起直接的促进作用,STAT3能否成为宫颈癌基因治疗的靶点有待于进一步研究。Objective： This study aimed at investigating STAT3 expression in cervical squamous intraepithelial lesions and their significance.Methods： By means of semi-quantitive RT-PCR,we haved evaluated STAT3 expression at mRNA levels in 13 cases cervicitis tissues,12 cervical intraepithelial neoplasia （CIN） Ⅰ、17 CINⅡ-Ⅲand 33 squamous cell carcinoma （SCC） tissues.Results： STAT3 expression showed no correlation with the grade of cervical intraepithelial lesions and clinical stage （P〉 0.10 respectively） ,positively correlated with pathological grade （r = 0.52,P 〈0.05） ,the group of vascular invasion and lymph node metastasis and depth of invasion 3mm were higher than those contrast lesion group （P 〈0.05 respectively）.Cox regression analysis showed that STAT3 expression has no relationship with poor prognosis of SCC.Conclusions： STAT3 can not directly contribute to the incidence and development of SCC,but plays a direct role in promoting SCC invasion,metastasis,differentiation.Anti-cancer therapeutic strategies targeting STAT3 for cervical cancer remains to be studied further.

关 键 词：信号转录和转录活化因子3 宫颈上皮内瘤变 宫颈鳞状上皮细胞癌 

分 类 号：R737.33[医药卫生—肿瘤]