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作 者:张艳红[1] 吕晓军 马香稳[1] 许华强[1] 孙乃英[1]
机构地区:[1]潍坊市妇幼保健院,山东潍坊261011 [2]潍坊市坊子区人民医院,山东潍坊261000
出 处:《中国优生与遗传杂志》2011年第1期33-34,共2页Chinese Journal of Birth Health & Heredity
摘 要:目的探讨Ki-67在胃癌组织浸润和转移中的表达和意义。方法采用SP免疫组化法检测64例胃癌组织中Ki-67基因表达情况。结果 Ki-67表达在淋巴结转移组高于无淋巴结转移组(P<0.01),在浸润组的表达高于无浸润组的表达(P<0.01),Ki-67在低分化组的表达高于中高分化组(P<0.01)。结论 Ki-67抗原表达的检测对评估胃癌的浸润与否,淋巴结转移与否以及胃癌分化程度有重要的意义,可帮助估计胃癌预后。Objective: To investigate the expression and significance of Ki-67 in tissue infiltration and diversion of Gastric Carcinoma.Methods: The expression of Ki-67 was detected by immunohistochemistry technique in 64 patients with gastric carcinoma.Results: The expression of Ki-67 in the group of transferred lymph node was higher than in the group of non-transferred lymph node (P 0.01).The expression of Ki-67 in the group of infiltrated tissue was higher than in the group of non-infiltrated tissue (P 0.01).The expression of Ki-67 in poorly differentiated group was higher than in midst-differentiated or well-differentiated group (P 0.01).Conclusion: Detection of Ki-67 antigen was helpful to evaluate infiltration status and the region lymph node status and the level of differentiation and the prognosis of gastric carcinoma.
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