RUNX3蛋白在肝癌组织中的表达及其意义  

Expression of RUNX3 protein in hepatic cell carcinoma and its clinicopathological implications

作　　者：卢燕辉[1,2] 郑瑞丹[1,2] 陈洁[1,2] 陈碧芬[1,2] 李建国[3] 林志川[3] 

机构地区：[1]解放军第175医院 [2]厦门大学附属东南医院肝病中心,福建漳州363000 [3]福建医科大学附属漳州市医院肝胆外科,福建漳州363000

出　　处：《南方医科大学学报》2011年第2期329-332,共4页Journal of Southern Medical University

基　　金：福建省自然科学基金(2009J01326)

摘　　要：目的探讨RUNX3蛋白在肝癌组织及其癌旁组织中的表达情况,并分析其与临床病理因素的相关性。方法采用免疫组织化学法检测RUNX3蛋白在肝癌组织及其癌旁组织中的表达水平,并分析其与临床病理因素的相关性。结果 RUNX3蛋白在肝癌组织、癌旁组织中的表达阳性率分别为49.02%(25/51)、82.35%(42/51),两者间有显著差异(χ2=12.5706,P<0.01)。RUNX3蛋白在分化程度、门静脉癌栓、肝内转移等病理因素的表达差异有统计学意义(P<0.05),而在性别、肿瘤直径、肿瘤部位、癌肿出血坏死、组织分型的表达差异无统计学意义(P>0.05)。结论 RUNX3蛋白在肝癌组织中的表达水平明显低于癌旁组织。RUNX3蛋白表达下调可能对肝癌的发生、发展具有重要作用,RUNX3基因可能是肝癌的抑癌基因。Objective To investigate the expression of RUNX3 protein in hepatic cell carcinoma（HCC） and its relationship with the clinicopathological factors of HCC.Methods Immunohistochemistry was performed to detect the expression of RUNX3 protein in HCC and the surrounding normal tissues,and the relation of RUNX3 with the clinicopathological factors of HCC was analyzed.Results The positivity rate of RUNX3 protein expression was 49.02%（25/51） in HCC tissues,significantly lower than that in the surrounding normal tissues [82.35%（42/51）,χ2=12.5706,P0.01）.RUNX3 protein expression varied significantly with such pathological factors as the differentiation degree,cancer-associated thrombosis in the portal vein and intrahepatic metastasis（P0.05）,but not with tumor diameter,location,tumoral hemorrhage,necrosis or histotypes of the tumor（P0.05）.Conclusion RUNX3 protein expression is lowered in HCC as compared with that in the surrounding normal tissue,suggesting an important role of RUNX3 in the tumorigenesis and development of HCC and the possible identity of RUNX3 gene as an anti-oncogene of HCC.

关 键 词：RUNX3蛋白 肝癌 免疫组织化学 临床病理因素 

分 类 号：R735.7[医药卫生—肿瘤]