涎腺腺样囊性癌COX-2表达与肿瘤血管生成的研究  

Study of COX-2 expression and angiogenesis in salivary adenoid cystic carcinoma

作　　者：李晓光[1] 袁丽丽[1] 肖长杰[1] 王延秀[2] 

机构地区：[1]泰安市中心医院口腔科,山东泰安271000 [2]泰安市中心医院麻醉科,山东泰安271000

出　　处：《临床口腔医学杂志》2011年第2期67-70,共4页Journal of Clinical Stomatology

基　　金：泰安市科技局资助项目(2007-46)

摘　　要：目的:探讨环氧化酶-2(Cycloxygenase-2,COX-2)表达与涎腺腺样囊性癌(salivary adenoid cystic carcino-ma,SACC)血管生成的关系。方法:免疫组化法检测SACC中COX-2、诱导型一氧化氮合酶(inducible nitric oxide synthase,iNOS)、血管内皮生长因子(vascular endothelial growth factor,VEGF)表达,并测定肿瘤微血管密度(microvessel density,MVD)。结果:SACC中COX-2表达与VEGF、iNOS表达密切相关(P<0.05,P<0.01)。SACC中COX-2表达阳性组和阴性组MVD有显著差异(P<0.01).结论:SACC中COX-2表达和肿瘤血管生成有关,iNOS和VEGF可能参与COX-2对肿瘤血管生成的促进作用。Objective：To explore the relationships between Cycloxygenase-2（COX-2） expression and angiogenesis in salivary adenoid cystic carcinoma（SACC）.Method：The COX-2 expression,inducible nitric oxide synthase（iNOS） and vascular endothelial growth factor（VEGF） expression,microvessel density（MVD） were evalulated by immunohistochemical method.Result：The expressions of COX-2 and iNOS、VEGF in SACC were significantly positively correlated（P0.05,P0.01）.There was significant difference of MVD between COX-2 positive SACC and negative ones（P0.05）.Conclusion：The present findings suggest that there is some link between COX-2 and angiogenesis in SACC,partly attributing to the effect of VEGF and iNOS.

关 键 词：涎腺腺样囊性癌 环氧化酶 血管生成 血管内皮生长因子 诱导型一氧化氮合酶 

分 类 号：R739.87[医药卫生—肿瘤] Q786[医药卫生—临床医学]