LN和LN-R在鼻腔鼻窦恶性肿瘤中表达的临床意义  

Clinical significance of LN/LN-R expression in nasal and paranasal sinus malignant tumor

作　　者：贾海英[1] 张涛[1] 山艳春[2] 莫天石 王继群[2] 

机构地区：[1]暨南大学附属第一医院耳鼻咽喉头颈外科,广东广州510632 [2]暨南大学医学院耳鼻咽喉科,广东广州510632 [3]澳门仁伯爵医院耳鼻咽喉科

出　　处：《中国病理生理杂志》2011年第2期284-287,共4页Chinese Journal of Pathophysiology

基　　金：广东省自然科学基金资助项目(No.9451063201003299);澳门科研基金委员会资助项目(No.029/2009/A)

摘　　要：目的:探讨层黏连蛋白(LN)及其受体(LN-R)在鼻腔鼻窦恶性肿瘤中表达的临床意义。方法:用免疫组化法检测137例鼻腔鼻窦恶性肿瘤、78例癌旁组织和37例对照组织中LN和LN-R的表达。结果:LN在鼻腔鼻窦恶性肿瘤中阳性表达率(13.87%)明显低于癌旁组(87.18%)和对照组(72.97%)(P<0.01),LN-R在鼻内翻性乳头状瘤中的阳性表达率(76.47%)明显高于鼻腔鼻窦恶性肿瘤(28.47%)、癌旁组织(10.26%)和鼻息肉或囊肿组织(10.0%)。LN-R在鼻腔鼻窦恶性上皮肿瘤和恶性软组织肿瘤中的表达存在显著差异(P<0.01),而LN的表达无显著差异(P>0.05)。结论:LN的减少为恶性肿瘤的侵袭和转移提供了条件,在鼻腔鼻窦恶性肿瘤中LN的检测将为临床治疗提供可靠依据。LN-R具有组织特异性,需根据不同病理类型进行深入研究。LN-R在鼻内翻性乳头状瘤中高表达,其机制有待进一步深入研究。AIM： To study the clinical significance of laminin/laminin receptor（ LN/LN -R） expression in nasal and paranasal sinus malignant tumor（NPMT）. METHODS ： The immunohistocbemical technique was used to detect the expression of LN and LN - R in 137 cases of NPMT, 78 cases of para - cancer tissues and 37 cases of non - cancer tis- sues. RESULTS： The positive rate of LN in NPMT（ 13.87% ） was significantly lower than that in para -cancer tissues （87.18%） and non - cancer tissues（72.97% ）, and the positive rate of LN - R in nasal inverting papilloma（76. 47% ） was significantly higher than that in NPMT（28.47% ）, para - cancer tissues（ 10. 26% ） and nasal polypus and cyst tissues （ 10. 0% ）. A significant difference of LN - R expression, but not LN, between endepidermis and soft tissue of the NPMT was observed（ P 〈 0. 01 ）. CONCLUSION： Decrease in LN expression provides the essential condition for the invasion and metastasis of the malignant tumor. Determining the expression level of LN in NMPT will be helpful for evaluation of tumor development and clinical management. High expression of LN - R only in the nasal inverting papilloma indicates that LN - R may play different roles in different pathotypes of NPMT.

关 键 词：层黏连蛋白 受体 层黏连蛋白 鼻咽肿瘤 

分 类 号：R739.6[医药卫生—肿瘤]