670例药物性肝损害分析  

A clinical analysis of 670 patients with drug-induced liver injury

作　　者：刘翠平[1] 邹衍泰[2] 白岚[2] 

机构地区：[1]南方医科大学南方医院消化内科,510515 [2]南方医科大学南方医院惠侨科,510515

出　　处：《现代消化及介入诊疗》2010年第6期338-340,共3页Modern Interventional Diagnosis and Treatment in Gastroenterology

摘　　要：目的探讨药物性肝损害的病因、临床特点及预后,为防治提供参考。方法选取670例诊断为药物性肝损害的住院患者,对其用药史、临床表现、肝功能及预后等进行回顾性分析。结果引起药物性肝病的前三位药物分别为抗肿瘤药物(18.8%)、中草药(13.3%)、抗结核药(12.5%);临床表现多为恶心、呕吐、乏力、纳差等非特异性症状。肝损害以肝细胞损害型最为常见,占420例(62.7%)。药物性肝损害患者的预后较好,其中治愈和好转率达82.7%。结论引起药物性肝病的药物种类繁多,由于药物性肝病临床表现无特异性,易误诊及漏诊,在有基础肝病者中更为常见,因此临床医师应提高对本病的认识,并应加大相关研究力度,重在预防和早期诊治。Objective To investigate the clinical features of drug-induced liver injury （DILI） and to improve the understanding of the disease. Methods Six hundred and seventy patients with DILI admitted to our hospital from 2001 to 2009 were reviewed retrospectively. Results Antitumor agents（18.8%）, Chinese herb medicine（13.3%） and antituberculosis drugs（12.5%） were the most common drugs causing liver injury. The main clinical manifestations included nausea, vomiting, fatigue, and anorexia. Hepatocellular injury was the most common type, which was seen in 420 cases. The drug-induced liver injury usually had a better prognosis than other liver diseases, and the overall cure and improvement rate was 82.7%. Conclusion Most kinds of drugs can induce liver injury. As the clinical manifestations of liver injury are different and non-specific, misdiagnosis and missed diagnosis of DILI were made by clinician, especially in the patients coexiting chronic liver disease.

关 键 词：药物性肝损害 慢性肝病 预后 

分 类 号：R575[医药卫生—消化系统]