功能性消化不良及其伴随精神症状与五羟色胺转运体基因多态性的关系  

Association of serotonin transporter gene polymorphisms with the development of functional dyspepsia and accompanying psychiatric symptoms

作　　者：韩仙芝[1] 高峰[2] 赵立群[2] 

机构地区：[1]郑州大学第一附属医院消化内科,河南省郑州市450052 [2]河南省(郑州大学)医药科学研究院,河南省郑州市450052

出　　处：《世界华人消化杂志》2010年第33期3599-3603,共5页World Chinese Journal of Digestology

基　　金：郑州市科技局科研攻关项目;No.0910SGYS33393-4~~

摘　　要：目的:探讨功能性消化不良(FD)及其伴随精神症状与五羟色胺转运体(SERT)基因多态性的关系.方法:采用多聚酶链式反应技术(PCR)检测60例FD患者与80例健康对照者SERT基因的启动子区(5-HTTLPR)和内含子2可变数目串联重复序列(VNTRs)的多态性.结果:5-HTTLPR区S等位基因频率在FD临床分型各组间以及有无精神症状各组间比较差异具有统计学意义(P<0.05).VNTRs区的多态性比较无统计学意义.结论:5-HTTLPR的S等位基因可能与FD-PDS亚型的发病以及FD患者伴随精神症状的发生有关.AIM： To investigate the association of serotonin transporter （SERT） gene polymorphisms with the development of functional dyspepsia （FD） and accompanying psychiatric symptoms. METHODS＂ Polymerase chain reaction （PCR） was used to detect the SERT gene-linked poly- morphic region （5-HTTLPR） and the variable number tandem repeats （VNTRs） in intron 2 of the SERT gene in 60 patients with FD and 80 healthy subjects.RESULTS： There are significant differences in 5-HTTLPR S allele frequencies among groups classified according to FD subtype and those ac- cording to psychiatric symptoms （all P 〈 0.05）. No significant differences were noted in geno- type distribution or allele frequency of VNTRs between controls and FD patient. CONCLUSION： The S allele of 5-HTTLPR may be associated with the development of FD-PDS subtype and FD-associated psychiatric symptoms.

关 键 词：功能性消化不良 情感障碍 五羟色胺转运体 基因多态性 

分 类 号：R57[医药卫生—消化系统] R749.2[医药卫生—内科学]