原发性肠道非霍奇金淋巴瘤穿孔的临床预后分析  

Prognosis of Primary Intestinal non-Hodgkin′s Lymphoma Perforation

作　　者：勾红峰[1] 陈心传[2] 

机构地区：[1]四川大学华西医院腹部肿瘤科,成都610041 [2]四川大学华西医院血液内科,成都610041

出　　处：《华西医学》2010年第11期1960-1963,共4页West China Medical Journal

摘　　要：目的对原发性肠道非霍奇金淋巴瘤穿孔患者的临床及病理特征、诊治、预后进行探讨。方法回顾性分析1999年1月-2008年12月诊治的17例原发性肠道非霍奇金淋巴瘤穿孔患者的临床资料。结果 B细胞型9例,T细胞型8例。17例原发肠道非霍奇金淋巴瘤穿孔患者的穿孔部位:大肠7例,小肠7例,回盲部3例。所有患者均行手术治疗。除2例穿孔前行化疗的患者以外,其余患者术前均未明确诊断。有14例获得随访结果,6例术后3个月内死亡,术后接受化疗者7例,1、2、3年生存率分别为41.2%、23.6%、11.7%,仅1例生存期超过5年。结论原发性肠道非霍奇金淋巴瘤穿孔术前诊断困难,预后极差。Objective To analyze the clinical features,diagnosis,therapy and prognosis of primary intestinal non-hodgkin′s lymphoma perforation.Methods The clinical data of 17patients with the primary intestinal non-Hodgkin′s lymphoma perforation from January 1999to December 2008were retrospectively analyzed.Results Nine patients had intestinal B-cell lymphoma,and eight had intestinal T-cell lymphoma.The sites of perforation were as follows：colon and rectum in 7（41.2%）,ileum and jejunum in 7（41.2%）,and ileocecal junction in 3（17.6%）.All patients had undergone the operations.The disease was not diagnosed before the operation in all of the patients except for the Two patients had a history of systemic chemotherapy before perforation.A total of 14patients were followed up,in whom six died within three months after the operation;the survival rate 1,2,and 3years after the operation was 41.2%,23.6%,and 11.7%,respectively in seven patients who had undergone the systemic chemotherapy before the operation;one patients lived more than 5years.Conclusion The diagnosis of primary colonic malignant lymphoma perforation is difficult;the prognosis is miserable.

关 键 词：肠肿瘤 淋巴瘤 穿孔 预后 

分 类 号：R735.3[医药卫生—肿瘤] R733.1[医药卫生—临床医学]