Pin1基因单核苷酸多态性与散发性阿尔茨海默病的相关性研究  

A case-control study of the association between single nucleotide polymorphisms of Pin1 gene with sporadic Alzheimer disease

作　　者：李超[1] 王燕[1] 伍力[1] 杨飏[1] 伍星[1] 余发春[1] 

机构地区：[1]云南省精神病医院老年精神病科,云南昆明650224

出　　处：《中风与神经疾病杂志》2011年第2期137-140,共4页Journal of Apoplexy and Nervous Diseases

摘　　要：目的探讨中国汉族人群中Pin1基因单核苷酸多态性与散发性阿尔茨海默病(sporadic Alzheimerdisease,SAD)的关系。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术,检测107例散发性阿尔茨海默病患者及110名正常对照的Pin1基因-667和-842位点基因多态性。结果 -667位点和-842位点SAD组和对照组基因型频率及等位基因频率差异均无统计学意义(P=0.098,P=0.102;P=0.835,P=0.594)。将-667位点的3种基因型分别与-842位点的2种基因型组合起来也未发现差异有统计学意义(P=0.523)。结论未发现中国汉族人群中Pin1基因-667和-842位点多态性与SAD有相关性。Objective To study of the association between SNP of Pin1 gene with sporadic Alzheimer disease（SAD） in Chinese Hun population.Methods To examine the genotypes distribution and alleles frequencies of-667 and-842 locus in Pin1 gene in 107 SAD patients and 110 healthy controls with PCR and restriction fragment length polymorphisms（RFLPs） technique.Results No statistical difference in the distribution of genotypes（P=0.098,P=0.835）or alleles（P=0.102,P=0.594）.Comparisons of the distribution of 6 types of genotype frequencies composed of three genotypes at-667 locus and two genotypes at-842 locus between the SAD group and control group did not show significant difference（P=0.523）.Conclusion Our data suggest that the polymorphisms of Pin1 gene may be not associated with SAD.

关 键 词：散发性阿尔茨海默病 Pin1基因 聚合酶链反应-限制性片段长度多态性 单核苷酸多态性 

分 类 号：R749.1[医药卫生—神经病学与精神病学]