TGF-β诱导上皮间充质转化的信号通路研究  

TGF-β signaling pathway in epithelial mesenchymal transition

作　　者：吴腾云[1] 张威[1] 曹冬梅[1] 

机构地区：[1]第二军医大学基础医学部病理生理学教研室,上海200433

出　　处：《国际病理科学与临床杂志》2011年第1期81-86,共6页Journal of International Pathology and Clinical Medicine

摘　　要：上皮间充质转化(epithelial-mesenchymal transition,EMT)是指上皮细胞脱黏附而转变成具有迁移能力的间质细胞的现象,它在胚胎发育、肿瘤转移及组织纤维化过程中都发挥重要的生理和病理作用。转化生长因子β(transforming growth factorβ,TGF-β)作为EMT发生过程中必不可少的诱导因子,经由Smad通路及Erk,PI3K/Akt,JNK/p38,WNT/GSK3/β-catenin等非Smad通路调节EMT的发生、发展。本文就TGF-β信号通路参与EMT过程的分子机制作一综述。During embryonic development and cancer metastasis or fibrosis,epithelial-mesenchymal transition（EMT） is a cellular process whereby epithelial cells disintegrate their intercellular contacts,organize their motility apparatus,and move to new locations.As a necessary inducer of EMT,transforming growth factor β（TGF-β） promotes and regulates EMT through Smad signaling-dependent or independent pathways,such as Erk,PI3K/Akt,JNK/p38,WNT/GSK3/β,catenin,etc.This article reviewed the molecular mechanisms of TGF-β signaling pathways in EMT.

关 键 词：转化生长因子Β 上皮间充质转化 信号转导 

分 类 号：R363[医药卫生—病理学]