多层螺旋CT灌注成像在非小细胞肺癌肿瘤血管生成评价中的应用  

Efficacy of multi-slice CT perfusion imaging for the evaluation of tumor angiogenesis in patients with non-small cell lung cancer(NSCLC)

作　　者：闫少宁[1] 平学军[1] 刘云[1] 

机构地区：[1]宁夏医科大学附属医院,宁夏银川750004

出　　处：《宁夏医学杂志》2011年第2期118-120,96,共3页Ningxia Medical Journal

摘　　要：目的探讨多层螺旋CT(MSCT)灌注成像在非小细胞肺癌(NSCLC)肿瘤血管生成评价中的应用。方法利用16层螺旋CT灌注成像技术研究经手术病理证实的42例周围型NSCLC(肺部恶性结节/肿块),记录MSCT灌注成像参数血流量(BF)、血容量(BV)、平均通过时间(MTT)和毛细血管表面通透性(PS)。对42例NSCLC组织标本采用免疫组织化学染色法测定肿瘤微血管密(MVD),对NSCLC的MVD计数与CT各项灌注参数进行相关性研究。结果 42例NSCLC的免疫组化MVD计数与BV、BF、PS之间呈显著直线相关关系。结论 NSCLC的CT灌注参数能够评价肿瘤微血管生成情况,是一种无创性、理想的活体肿瘤血管检查方法。Objective To evaluate efficacy of multi-slice CT perfusion imaging for tumor angiogenesis in patients with non-small cell lung cancer（NSCLC）.Methods 42 patients with peripheral NSCLC（malignant pulmonary nodules or masses） proved by pathology were studied with 16-slice spiral CT perfusion scanning.Four CT perfusion parameters of NSCLC including blood flow（BF）,blood volume（BV）,mean transit time（MTT）,and permeability surface（PS） were recorded.Mircrovessel density（MVD） of tumor in 42 Pathologic specimens of NSCLC were determined by immunohistochemistry staining,and then MVD of NSCLC was correlated with its CT perfusion parameters.Results The BV,BF and PS of 42 cases of NSCLC positively correlated with MVD.Conclusion The CT perfusion parameters of NSCLC can evaluate tumor angiogenesis of NSCLC.It is a non-invasive and ideal way to evaluate tumor angiogenesis in living body.

关 键 词：X线计算机 灌注成像 微血管密度 肺肿块 NSCLC 

分 类 号：R734.2[医药卫生—肿瘤]