血浆同型半胱氨酸与中青年脑梗死关系的研究  

Study on Relationship between Piasma Homocysteine and Ischemic Stroke in Young and Middle-Aged Adults

作　　者：石炎川[1] 陈跃鸿[1] 原敏[2] 黄庆文[3] 吴瑞明[4] 杨妙雄[1] 郭婷辉[1] 陈文伙[1] 

机构地区：[1]福建医科大学附属漳州市医院神经内科,福建省漳州市363000 [2]福建医科大学附属漳州市医院检验科,福建省漳州市363000 [3]福建医科大学附属漳州市医院核磁共振室,福建省漳州市363000 [4]福建医科大学附属漳州市医院彩超室,福建省漳州市363000

出　　处：《中华全科医学》2011年第3期380-381,共2页Chinese Journal of General Practice

摘　　要：目的研究血浆同型半胱氨酸水平与中青年脑梗死的关系,探讨血浆同型半胱氨酸水平与中青年脑梗死病灶体积和病情严重程度的关系。方法应用循环酶法测定132例中青年脑梗死患者及86例健康对照者的血浆同型半胱氨酸水平,并进行比较。结果脑梗死组与对照组血浆同型半胱氨酸水平升高分别为81例和16例,各占61.4%和18.6%,同型半胱氨酸水平分别为(24.32±5.68)μmol/L和(12.58±3.53)μmol/L,两组比较有统计学意义(P<0.01)。血浆同型半胱氨酸水平越高,急性期脑梗死的病灶越大,两者呈直线正相关关系。结论高同型半胱氨酸血症(HH)是中青年脑梗死的危险因素,HH在中青年中发病率较高,血浆同型半胱氨酸水平越高,急性期脑梗死的病灶越大,与病情严重程度有关;血浆同型半胱氨酸水平能反映脑梗死灶的大小及病情程度,对有脑血管病倾向的中青年,血浆同型半胱氨酸检查应作为常规检查或作为病情监测和预后判断的重要指标。Objective To investigate the relationship between plasma level of homocysteine（Hcy） and ischemic stroke in young and middle-aged adults, and observe the relationship between change of plasma level of homocysteine and the size of the infarcted focus and the degree of disease in patients with ischemic stroke among young and middle-aged adults. Methods The plasma homocysteine level of 132 young and middle-aged adults patients with ischemic and 86 control peoples were measured by means of enzymatic cycling assay. Results There were 81 cases and 16 cases whose Hcy levels increased respectively,which accounted for 61.4% and 18.6% with serum concentration being（24.32 ±5.68）μmol/L and（ 12.58 ±3.53） μmol/L, respectively. The difference was significant statistically （P 〈 0.01 ）. The area of infarcted focus increased with the level of plasma homocysteine in acute ischemic stroke group of young and middle-aged adults. The plasma homocysteine level and the infarcted focus were posi- tively linearly correlated. Conclusion Hyperhomocysteinemia（HH） is a risk factor of ischemic stroke among young and middle- aged adults, and HH is common in infarcted focus. The area of infarcted focus increased with the level of plasma homocysteine in acute ischemic stroke group. The plasma homocysteine level can reflect the size of the infarcted focus and the degree of disease, and correlated with the degree of the severity; and the plasma homocysteine level should serve as a kind of regular examination or as an index intervention can be taken.

关 键 词：血浆同型半胱氨酸 中青年 脑梗死 循环酶法 

分 类 号：R743.33[医药卫生—神经病学与精神病学]