学龄前单纯性肥胖儿童β_3-AR基因变异及气质类型分析  

Detection and significance of Trp64Arg mutation of β_3-AR and temperament in preschool children with simple obesity

作　　者：彭安娜[1] 杨少萍[1] 张斌[1] 张丹[1] 陈忠[1] 胡唏江[1] 覃凌智[1] 杨艳[1] 

机构地区：[1]湖北省武汉市妇女儿童医疗保健中心,430015

出　　处：《中国学校卫生》2011年第2期186-187,共2页Chinese Journal of School Health

基　　金：武汉市青年科技晨光计划(200750731291)

摘　　要：目的了解β3-AR基因变异及气质与儿童单纯性肥胖的关系,为控制儿童单纯性肥胖提供实验依据。方法对随机整群抽取的武汉市714名儿童的β3-AR基因型进行检测,并测量体重、身高,测查儿童气质类型。结果肥胖儿童β3-AR不同等位基因间的气质类型分布差异有统计学意义。男童肥胖组中间偏麻烦型、麻烦型和启动缓慢型与对照组中间偏平易型、平易型的构成差异有统计学意义;女童肥胖组和对照组儿童各气质类型差异无统计学意义。结论基因变异从不仅从生理角度影响儿童的肥胖,还其与儿童心理过程的速度和稳定性、强度及指向性有关,需要进一步探讨。Objective To investigate the β3 adrenergic receptor gene （ β3 - AR） Trp64Arg mutation and temperament in pre-school children with simple obesity in Wuhan. Methods β3 - AR genotypes were detected and weight and height were measured in 714 children. Temperament style was assessed by using Chinese-version software. Results The difference of temperament style in different β3 - AR gene was statistically significant, there was significant difference between simple obese boys＂ and normal weight boys＂ temperament types. Conclusion The Trp64Arg Mutation of β3 -AR distribution in pre-school children with simple obesity is related with temperament types which is needed further study.

关 键 词：肥胖症 基因转变 气质 儿童 学龄前 

分 类 号：B848.1[哲学宗教—心理学] R394.112[医药卫生—医学遗传学]