ERCC1在非小细胞肺癌中的表达及预后意义  

Expression and Prognostic Significance of ERCC1 in Non-small Cell Lung Cancer

作　　者：邓首军[1] 郭刚[1] 陈楠[1] 李高峰[1] 

机构地区：[1]昆明医学院第三附属医院胸外科,昆明650118

出　　处：《医学综述》2011年第3期460-462,共3页Medical Recapitulate

摘　　要：目的探讨DNA修复因子ERCC1蛋白在非小细胞肺癌中表达的临床意义及其与NSCLC预后的关系。方法收集117例非小细胞肺癌组织石蜡标本制成组织芯片,利用免疫组化SP法检测ERCC1的表达,分析其与临床各因素的关系。结果 117例NSCLC组织中ERCC1蛋白的阳性表达率为39.3%,ERCC1在肺癌组织和正常肺组织中的表达有统计学差异(P<0.01)。ERCC1的表达与肺癌分化程度和组织学分型密切相关(P<0.05),ERCC1阳性表达组5年生存率(41.6%)高于阴性表达组(28.0%)(P<0.05),ERCC1表达与NSCLC的预后相关。结论 ERCC1阳性者预后较好,提示其表达对预后评估有一定的指导价值。Objective To study the clinical and prognostic significance of DNA repairing factor ERCC1 protein in non-small cell lung cancer（NSCLC）.Methods Paraffin sections of NSCLC specimens（n=117）were collected for the preparation of tissue chips.Expression of ERCC1 was examined by using SP immunohistochemistry to analyze the associations with clinical factors.Results In NSCLC tissue,the positive expression rate of ERCC1（n=117）was 39.3%,whereas the expression of ERCC1 did not differ significantly between NSCLC tissue and normal lung tissue（P0.05）.The expression of ERCC1 was closely associated with NSCLC differentiation and histological type（P0.05）.The five-year survival rate of ERCC1-positive group was higher than that of negative group（41.6%vs.28.0%,P0.05）,showing that the expression of ERCC1 was associated with the prognosis of NSCLC.Conclusion ERCC1-positve patients have a favorable prognosis,suggesting the role of ERCC1 in the evaluation of NSCLC prognosis.

关 键 词：肺肿瘤 组织芯片 预后 ERCC1蛋白 

分 类 号：R734.2[医药卫生—肿瘤]