烟酰胺磷酸核糖转移酶的调控因素及药物作用  

The regulatory factors and drug effects of nicotinamide phosphoribosyl transferase

作　　者：吕小群[1] 张偌瑜[1] 缪朝玉[1] 

机构地区：[1]第二军医大学药理学教研室,上海200433

出　　处：《药学实践杂志》2011年第1期11-14,共4页Journal of Pharmaceutical Practice

基　　金：国家973计划课题(2009CB521902);国家"重大新药创制"科技专项(2009ZX09303-002);上海市优秀学科带头人计划(10XD1405300);上海市血管生物学重点实验室开放课题基金(GXY2009001001)

摘　　要：烟酰胺磷酸核糖转移酶(Nampt)是生命过程中不可或缺的蛋白,具有多种生理功能,对许多疾病如心脑血管疾病、糖尿病、癌症、自身免疫性疾病等有潜在的作用。阐明各种生理、病理状态以及化合物对Nampt表达水平的改变,可为Nampt的基础性和应用性研究起到推动作用。本文就各种因素对Nampt转录、表达调控的研究进展进行了较为系统的综述。nicotinamide phosphoribosyl transferase （Nampt） is an essential protein with a variety of physiological functions and performs potential functions on many diseases such as cardiovascular diseases, diabetes, cancer and autoimmune diseases. It is of great significance to clarify the effect of physiological and pathological statuses as well as compounds on the expression level of Nampt, as it will promote the basic and applied researches. A systematic review about various factors regulating the transcription and expression of Nampt were carried out in this paper.

关 键 词：NAMPT 调控 生理 病理 化合物 

分 类 号：R965[医药卫生—药理学]