乳癌VEGF表达、微血管密度与腋窝淋巴结转移的关系  

RELATIONSHIP BETWEEN VEGF EXPRESSION AND ANGIOGENESIS IN LYMPHNODE POSITIVE AND NEGATIVE STATUS OF BREAST CARCINOMA

作　　者：武利存[1] 张维东[1] 刘惠萍[2] 张庆慧[3] 孙公甲[1] 

机构地区：[1]山东省医学科学院基础医学研究所 [2]济南市中心医院病理科 [3]山东医科大学病理学教研室

出　　处：《山东医科大学学报》1999年第3期189-191,共3页Acta Academiae Medicinae Shandong

基　　金：山东省科委科研基金

摘　　要：对 ３５ 例乳癌石蜡切片分别用抗血管内皮生长因子（ Ｖ Ｅ Ｇ Ｆ）和抗八因子相关抗原（Ⅷ Ｆ Ｒ Ａｇ）单抗进行免疫组化染色，以探讨 Ｖ Ｅ Ｇ Ｆ 的表达水平、微血管密度（ Ｍ Ｖ Ｄ）及腋窝淋巴结转移之间的关系。结果显示，腋窝淋巴结有转移者 Ｖ Ｅ Ｇ Ｆ 阳性率和 Ｍ Ｖ Ｄ 分别为 ７７７８％ 和 ９３８２±２１７６，无转移者为１７６８％ 和 ４３５０±１１０３，二者呈正相关。 Ｖ Ｅ Ｇ Ｆ 表达和 Ｍ Ｖ Ｄ 不仅可作为乳癌预后指标，而且通过抑制 Ｖ Ｅ Ｇ Ｆ 表达和抗血管生成治疗可防止肿瘤复发和转移。对选择其他疗法亦有参考价值。Vascular endothelial growth factor (VEGF) immunostaining was employed to determine VEGF expression level in this investigation. Intratumoral microvessels were highlighted by immunocytochemical staining using monoclonal antibody for ⅧF RAg. The results showed that, in the metastatic node group, the positive rate of VEGF and MVD are 77.78% and 93.82±21.76, respectively; whereas in the node negative group, they are 17.68% and 43.50±11.03, respectively. Namely, the expression of VEGF correlates with tumor angiogenesis. So VEGF and MVD are two significat indicators of breast carcinoma. Furthermore, inhibition of VEGF expression and antiangiogenesis therapy may be novel approaches to prevent cancer relapse and metastasis.

关 键 词：内皮生长因子 微血管密度 淋巴结转移 乳癌 

分 类 号：R737.9[医药卫生—肿瘤] R733.4[医药卫生—临床医学]