合用氯丙嗪和PQP对脑缺血的保护作用  

Protection of potassium quercetin phosphate combined with chlorpromazine on cerebral ischemia-reperfusion injury in rats

作　　者：鲁达智 王志平[2] 

机构地区：[1]宜兴市医药总公司,宜兴214200 [2]山西医科大学药理学教研室

出　　处：《山西医科大学学报》1999年第3期203-205,共3页Journal of Shanxi Medical University

摘　　要：用四动脉结扎法造成大鼠急性脑缺血４０ ｍｉｎ 再灌１ ｈ 的模型，观察合用氯丙嗪和槲皮素磷酸酯钾（ Ｐ Ｑ Ｐ） 的作用并探讨其机制。结果表明，在缺血前５ ｍｉｎ 和再灌前５ ｍｉｎ 各静注一次氯丙嗪３ ｍｇ·ｋｇ１ 和 Ｐ Ｑ Ｐ１０ ｍｇ·ｋｇ１ ，可明显降低脑钙和 Ｍ Ｄ Ａ 含量，保护 Ｓ Ｏ Ｄ 活性，减轻脑水肿，缓解脑损伤引起的 Ｌ Ｄ Ｈ 释放，改善 Ｅ Ｅ Ｇ。但同样剂量的氯丙嗪或 Ｐ Ｑ Ｐ 单独使用时，对上述指标并无明显影响。提示两药合用后作用明显增强，其机制与防止钙在脑组织积累、保护 Ｓ Ｏ Ｄ 活性及抗脂质过氧化等有关。To observe the protection of PQP combined with CPZ on cerebral ischemia-reperfusion injury and study the mechanism of its action.The animal model was performed by 40 min four vessel occlusion and 1 h subsequent release in rats.When PQP 10 mg.kg -1 iv and CPZ 3 mg.kg -1 iv were used in combination 5 min before ischemia and the second one 5 min berore release,they significantly declined calcium accumulation (P<0 01) and MDA content (P <0 01),protected activation of SOD (P <0 01) ,inhibited brain edema (P <0 01) and LDH releasing from brain tissues (P <0 01) ,improved EEG.But when PQP or CPZ was used singly in the same dose,no remakable effects were observed on above-mentioned indexes.The results suggest that the two drugs used in combination show noticeable synergism,and the mechanism be associated with preventing the calcium accumulation in brain tissue,protecting the activation of SOD,and resisting lipid peroxidation.

关 键 词：氯丙嗪 槲皮素磷酸酯钾 脑缺血 再灌注损伤 

分 类 号：R743.31[医药卫生—神经病学与精神病学] R972[医药卫生—临床医学]