经股动脉药盒导管植入系统治疗晚期恶性肿瘤  

Intervention treatment with percutaneous trans arterial implantation of port catheter system for advanced cancer patients

作　　者：黄金华[1] 吴沛宏[1] 张福君[1] 崔随平 周毅[3] 

机构地区：[1]中山医科大学肿瘤医院影像介入科,广州510060 [2]河南省驻马店市人民医院内科 [3]江门市中心医院外科

出　　处：《中华肿瘤杂志》1999年第5期386-388,共3页Chinese Journal of Oncology

摘　　要：目的　探讨应用经皮股动脉穿刺药盒导管植入系统（ＰＣＳ） 对晚期恶性肿瘤进行介入治疗的可行性、临床疗效、并发症及其处理。方法　经ＰＣＳ化疗灌注和（ 或） 化疗栓塞治疗５３ 例晚期恶性肿瘤，其中原发性肝癌２４ 例，肝转移瘤１３ 例，胰腺癌２ 例，胃癌２ 例，宫颈癌术后复发７ 例，直肠癌术后盆腔转移３ 例，盆腔横纹肌肉瘤１ 例，左髂骨尤文氏肉瘤１ 例。每４～６ 周为一疗程。结果　５３例患者经ＰＣＳ治疗后生存期５～１８ 个月，中位生存期１３ ．５ 个月，有效率（ＣＲ＋ ＰＲ）６２ ．３％ （３３５３） 。并发症主要有留置管移位滑脱２ 例，拆线后切口裂开１ 例，药盒部位皮肤坏死１ 例。全组未发生局部感染、出血等并发症及留置管堵塞现象。结论　经皮股动脉ＰＣＳ植入术操作简便、安全，不影响患者日常生活。ＰＣＳ能长期留置，并按照化疗药物的药代动力学特点对肿瘤进行化疗。Objective To examine the feasibility, clinical efficacy and complications of percutaneous trans arterial implantation of port catheter system (PCS) for intervention treatment of advanced malignant tumors. Methods Fifty three cases with advanced malignant tumors were treated by infusion of chemotherapeutic drugs and/or chemo embolization through PCS. Patients received one course of treatment every 4～6 weeks. Results In this series of treated patients, the survival period was 5～18 months with a mean survival time of 13.5 months. The overall response rate (CR+PR) was 62.3%. Detachment of the catheter tip occurred in 2 cases. Disruption of wound after removal of stitches occurred in one case and skin necrosis at the port occurred in another.Conclusion Long term intervention treatment with PCS is simple and safe. It is a treatment of choice for patients with advanced malignancy.

关 键 词：肿瘤 PCS 药物疗法 化学栓塞 

分 类 号：R730.53[医药卫生—肿瘤]