南海链霉菌SCSIO 1635中抗霉素类化合物的分离鉴定(英文)  

Antimycins from Marine Streptomyces sp. SCSIO 1635 from the South China Sea

作　　者：李苏梅[1] 田新朋[1] 牛四文[1] 张文军[1] 张偲[1] 鞠建华[1] 张长生[1] 

机构地区：[1]中国科学院南海海洋研究所海洋生物资源可持续利用重点实验室(海洋微生物研究中心广东省海洋药物重点实验室,广州510301

出　　处：《天然产物研究与开发》2011年第1期10-14,42,共6页Natural Product Research and Development

基　　金：supported by the Funds of the Chinese Academy of Sciences for Key Topics in Innovation Engineering(KZCX2-YW-216,KSCX2-YW-G-065,KSCX2-YW-G-073);Natural Science Funds of South China Sea Institute of Oceanology for Young Scholar(SQ200903);Funds of Frontier Areas of SCSIO (LYQY200805);Open Project Program of Key Laboratory of Marine Bio-resources Sustainable Utilization(LMB091013)

摘　　要：我们从南海海底沉积环境分离了一株放线菌SCSIO1635,经16S rDNA的序列分析将该株菌鉴定为链霉菌属。我们从该菌的发酵液中分离得到了4个化合物,经质谱和核磁共振波谱解析,确定为抗霉素类化合物:异构体antimycin A1a和A1b(1)、deisovalerylblastmycin(2)、kitamycin A(3)和antimycin A9(4)。The strain SCSIO 1635 was isolated from marine sediment of the South China Sea,and identified as a member of Streptomyces according to the 16S rDNA sequence. Four compounds were isolated from Streptomyces sp. SCSIO 1635. The compounds were found to be structurally-related to antimyeins by detailed analyses of MS and NMR spectroscopic data ,and were identified as antimyein A1, and A1b （ 1 ）, deisovalerylblastmyein （2）, kitamycin A （3）, and antimyein A9 （4）, respectively.

关 键 词：南海沉积环境 海洋放线菌 海洋微生物天然产物 链霉菌 抗霉素 

分 类 号：Q936[生物学—微生物学] R284.1[医药卫生—中药学]