内皮细胞与三叉神经脱髓鞘的关系探讨  

The relationship between vascular endothelial cells and trigeminal demyelination

作　　者：叶廷军[1] 刘会敏[1] 陈泳莲[1] 姜晓钟[2] 

机构地区：[1]第二军医大学长征医院病理科,200003 [2]第二军医大学长征医院口腔科

出　　处：《实用口腔医学杂志》1999年第5期355-357,共3页Journal of Practical Stomatology

摘　　要：目的：探讨血管内皮细胞与三叉神经脱髓鞘病变的关系，为临床解释脱髓鞘病因发生提供依据。方法：分别选用描写、轻度、中度、脱髓鞘组进行免疫组化表达，对内皮细胞、淋巴细胞在病变处分布变化进行定量分析。结果： Ｃ Ｄ３１、 Ｆ８ 的表达证实病变处血管内皮细胞突起和塌陷。 Ｃ Ｄ３、 Ｃ Ｄ４５ Ｒ Ａ 表达病变均有淋巴细胞参与。描写、轻度组与中度、脱髓鞘组的血管内皮细胞与淋巴细胞计数相比较，差异显著（ Ｐ＜ ０．０５ 或 Ｐ＜ ０．０１）。结论：血管内皮细胞在脱髓鞘病变中，可激活淋巴细胞，也可输送淋巴细胞参与免疫应答。因此，阻止内皮细胞的病变具有重要意义。Objection:To study the reason of trigeminal demyelination.Methods:The lesion were divided into four groups including describing, light,moderate and demyelination group.The changes of lymphocytes and vascular endothelium in local area of demyelination were observed with quantitative analysis.Results:Protrusion or sink of vascular endothelium with CD 31 and F8 expression were observed.Lymphocytes with CD 3 and CD 45RA expression were also found in the lesions. There was significant difference of the findings between the group of describing and light lesion ( P <0.05),and the group of moderate and demyelination ( P <0.01).Conclusion:Vascular endothelium in demyelination may activate lymphocytes and transfer lymphocytes to the area of lesion involving immune reaction.

关 键 词：神经组织 脱髓鞘疾病 血管内皮 免疫组织化学 

分 类 号：R744.5[医药卫生—神经病学与精神病学]