靶向纳米探针介导的近红外激光热疗  

Near-infrared Region Photothermal Therapy using Targeting Nanoprobe

作　　者：周非凡[1] 宋盛[1] 吴宝艳[1] 欧忠敏[1] 邢达[1] 

机构地区：[1]华南师范大学生物光子学研究院激光生命科学研究所,暨激光生命科学教育部重点实验室,广东广州510631

出　　处：《激光生物学报》2011年第1期125-129,共5页Acta Laser Biology Sinica

基　　金：科技部国家重点基础研究973计划项目(2010CB732602;2011CB910402);教育部"长江学者与创新团队计划"创新团队项目(IRT0829);国家自然科学基金项目(30870676;30870658;30800261)

摘　　要：肿瘤靶向治疗的研究是当今生物医学界的研究热点。本研究采用整合素αvβ3单克隆抗体作为肿瘤靶向分子,以单壁碳纳米管(SWNT)作为运输裁体,同时利用单壁碳纳米管在近红外区的光吸收特性,开展靶向肿瘤光热治疗。实验结果表明,这种整合素αvβ3单抗标记的碳纳米管探针对高表达αvβ3的U87MG细胞具有高靶向选择性和靶向光杀伤性,能成为一种有潜力的靶向光热转换探针应用于新型肿瘤靶向治疗。The pursuit of efficient and highly target-selective transporters is an active topic in cancer targeting therapy. Here, a novel functioned nanoprobe based on integrin αvβ3 monoclonal antibody labeled carbon nanotubes was developed to targeting and killing cancer cells under laser irradiation. The results revealed that the nanoprobe had a high efficiency in cancer cell targeting and killing in integrin αvβ3 positive U87MG ceils, could be used as a potential photothermal transductiou nanoprobe for cancer targeting therapy.

关 键 词：肿瘤靶向治疗 碳纳米管 光热治疗 靶向探针 

分 类 号：R73-362[医药卫生—肿瘤]