治萎防变胶囊对CAG模型大鼠血浆ET-1含量和胃组织氧自由基域的影响  

Effect of Zhiweifangbian Capsule on Content of ET-1 in Plasma and Oxygen Free Radical Threshold in Gastric Tissues of Rats with Chronic Atrophic Gastritis

作　　者：成映霞 段永强[1] 朱立鸣 李万义 

机构地区：[1]甘肃中医学院基础课部,甘肃兰州730020 [2]甘肃省清水县人民医院,甘肃清水741400

出　　处：《中国中医基础医学杂志》2011年第2期174-176,共3页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：甘肃省中医管理局科技计划项目(07-GZK-07);甘肃中医学院中青年基金项目(05ZQ-03/09ZQ-9)

摘　　要：目的:探讨治萎防变胶囊对CAG模型大鼠血浆ET-1含量和胃组织氧自由基域的影响。方法:采用综合法复制CAG病理模型。施药治疗后对各组大鼠血浆ET-1、胃组织SOD、GSH-Px及MDA、LPO水平进行检测。结果:与空白组比较,模型组大鼠血浆ET-1含量显著升高(P<0.01),胃组织SOD、GSH-Px活性显著下降(P<0.01,P<0.05),MDA、LPO含量显著升高(P<0.01);与模型组比较,治萎防变胶囊可显著降低血浆ET-1含量(P<0.05),显著提高SOD、GSH-Px活性(P<0.05)并降低MDA、LPO含量(P<0.05),且以治萎防变胶囊大剂量作用显著。结论:治萎防变胶囊具有增加胃黏膜血流量,改善微循环和提高机体抗氧化酶活性,减轻自由基损伤并抑制脂质过氧化物反应的作用。Objective：To study effects of Zhiweifangbian capsule（ZWFB） on content of ET-1 in plasma and oxygen free radical threshold in gastric tissue of rats with chronic atrophic gastritis.Methods：Model of chronic atrophic gastritis was established with synthetic method.After treated with ZWFB,the content of ET-1 in plasma,activity of SOD,GSH-Px and content of MDA,LPO in gastric tissue were detected.Results：In successful model group,content of ET-1 in plasma was much higher than that of normal group（P0.01）,activity of SOD,GSH-Px were much lower than those of normal group（P0.01,P0.05）,content of MDA,LPO were much higher than those of normal group（P0.01）.Compared with model group,ZWFB could decrease content of ET-1 in plasma（P0.05）,increase activity of SOD,GSH-Px（P0.05） and decrease content of MDA,LPO（P0.05） significantly.Conclusion：It was suggested that ZWFB has functions of ameliorating gastric mucosal blood flow and microcirculation;elevating antioxidation enzyme activity,lessening free radical impairment and restraining lipid peroxidation.

关 键 词：治萎防变胶囊 慢性萎缩性胃炎 血浆 ET-1 胃组织 SOD GSH-PX MDA LPO 

分 类 号：R573.32[医药卫生—消化系统]