牛磺酸对大鼠血清T3、T4及脑组织锌含量的影响  

The effect of taurine on content of T3,T4 in rat′s serum and of Zn^(2+) in cerebral frontal cortex and hippocampal

作　　者：张文革[1,2] 王勇[3] 胡建民[2] 

机构地区：[1]鞍山师范学院附属卫生学校,辽宁鞍山114001 [2]沈阳农业大学,沈阳110161 [3]辽宁科技大学,辽宁鞍山114044

出　　处：《中国卫生检验杂志》2011年第1期95-96,100,共3页Chinese Journal of Health Laboratory Technology

基　　金：国家自然科学基金项目(30371048)

摘　　要：目的:为了探索牛磺酸(Tau)的增智机理。方法:本文用Morris迷宫学习记忆模型,对大鼠在不同时期补充或抑制牛磺酸的吸收影响大鼠血清中T3、T4及大脑前额叶和海马中Zn含量进行比较。结果:发现适当补充牛磺酸可以提高血清T3及大脑前额叶、海马中Zn的含量,但是没有显著差异,含量的多少与学习成绩好坏基本吻合。而抑制牛磺酸的吸收可以明显降低血清T3的含量,而且与对照组比较有显著差异;抑制牛磺酸的吸收可以降低大脑中前额叶与海马的锌含量,但没有显著差异。结论:缺乏牛磺酸在胚胎初期可降低血清T3含量,从而影响甲状腺激素的合成;由于降低了对学习记忆非常重要的Zn的含量,从而影响了大鼠学习记忆能力。这可能是牛磺酸提高学习记忆能力的部分原因。Objective：To explore into the mechanism of the function of taurine on improving intelligence.Methods： Morris water test maze training combined with the content of T3,T4 in serum and Zn2＋ in cerebral frontal cortex and hippocampal were used to investigate the possible effects of supplementing Taurin or its depressor-β-Alanine in different periods.Results： The results indicated adding properly taurine can improve the ability of rat′s learning and memory and accompanied by the increase of T3 content in serum and the Zn2＋ in cerebral frontal cortex and hippocampal,but there is no obvious difference in the whole thyroidotoxin content in different groups.Conclusion： Taurine can enhance the intelligence through improving the content of T3 in serum,Zn2＋ in cerebral frontal cortex and hippocampal.This is probably one of the mechanisms of the function of taurine on improving intelligence.

关 键 词：牛磺酸 Β-丙氨酸 学习记忆 T3 T4 锌 

分 类 号：R961[医药卫生—药理学]