晚发性抑郁患者睡眠障碍的多导睡眠图研究  

Study on the physiological changes of the late-onset depression during sleep

作　　者：邢秀颖[1] 许晶[1] 王俊平[1] 周密[1] 

机构地区：[1]中国传媒大学校医院内科,北京100024

出　　处：《中华行为医学与脑科学杂志》2011年第2期131-133,共3页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：基金项目：国家自然科学基金资助项目（30570477）

摘　　要：目的探讨晚发性抑郁患者睡眠障碍的多导睡眠图特点。方法15例晚发性抑郁患者与10例健康老年人分别进行汉密尔顿抑郁量表（Hamihon Depression Scale，HAMD）的评分、多导睡眠记录仪的监测，次日行日间功能评定。结果与对照组比较，晚发性抑郁患者睡眠进程明显紊乱，其中睡眠效率[（59．20±2．90）％，（77．09±1．55）％]、睡眠潜伏期[（54．00±4．97）min，（24．00±2．91）min]、异相睡眠（rapid eye nlovetllent，REM）次数[（4．50±0．40），（2．63±0．26）]和REM睡眠潜伏期（REM latency，REML）[（51．40±2．97）min，（79．00±3．56）min]差异有显著性（P〈0．01）；与对照组比较，晚发性抑郁组的醒觉时间及百分比[（31．84±3．47）％，（18．17±1．95）％]增加，S2睡眠时相的时间[（116．40±11．16）min，（199．25±11．84）min]及百分比[（31．00±2．60）％，（48．67±1．46）％]明显增加，慢波睡眠时间减少，REM睡眠活动度、密度[（58．61±3．76），（40．64±1．88）]及强度增加护〈0．05）。结论晚发性抑郁患者存在客观睡眠生理指标的紊乱；S2睡眠时间及百分比的增加、REM睡眠去抑制的表现有可能成为晚发性抑郁患者特异性的诊断指标。Objective To explore the physiological changes of the late-onset depressive（LOD） persons during sleep. Methods 15 cases of LOD patients formed a group and 10 healthy aging persons formed a control group. Hamilton Depression Scale （HAMD） was used to score the severity of depression and polysomnographic recorders were used to monitor the whole night long. The subjective feelings of the sleep and the daytime mental sta- tus were assessed in the morning. Results Compared with the controlde group, the LOD patients obviously possessed a disordered sleeping process ： sleep efficiency was lower （ （ 59.20 ± 2.90 ） % , （ 77.09 ± 1.55 ） % , P 〈 0.01 ） ; their sleep latency was longer（ （54.00 ± 4.97 ） , （ 24.00± 2.91 ） , P 〈 0.01 ） ; the numbers of rapid eye movement（REM） sleep phase and rapid eye movement latency（REML） were strikingly different（P〈 0.01 ）. Com- pawrl with the control group,the LOD patients＇ awakening time and percent were significantly increased. Not only were the time and percentage of S2 sleep phase much higher,but the time of slow wave sleep was shorter. Besides, REM sleep activity,its density, and its intensity were raised （P 〈 0.05 ）. Conclusion There is a disturbance of the objective physiological indexes happening among the LOD patients. The increase of S2 sleeping time and percentage and the disinhibition of REM sleep can be used as the diagnosis indexes of LOD patients＇ specificity.

关 键 词：晚发性抑郁症 多导睡眠图 快速眼动睡眠 去抑制 

分 类 号：R749.4[医药卫生—神经病学与精神病学]