A new friedelane triterpenoid and saponin with moderate antimicrobial activity from the stems of Drypetes laciniata  

作　　者：Simone Veronique Fannang Victor Kuete Celine Mbazoa Djama Marlise Diane J.Dongfack Jean Duplex Wansi Francois Tillequin Elisabeth Seguin Elizabeth Chosson Jean Wandji 

机构地区：[1]Laboratoire de Synthese et de Produits Naturels,Departement de Chimie Organique de l'Universite de Yaounde-1,Faculte des Sciences,P.O.Box 812 Yaounde,Cameroon [2]Department of Biochemistry,University of Dschang,Faculty of Science,P.O.Box 67 Dschang,Cameroon [3]Laboratoire de Pharmacognosie de l'Universite Paris Descartes,UMR/CNRS No.8638,Faculte des Sciences Biologiques et Pharmaceutiques,4-Avenue de l'Observatoire,75006 Paris,France [4]Department of Chemistry,University of Douala,Faculty of Science,P.O.Box 24157 Douala,Cameroon [5]Laboratoire de Pharmacognosie,UFR de Medecine Pharmacie Rouen,22-Bld Gambetta,76183 Rouen Cedex 1,France

出　　处：《Chinese Chemical Letters》2011年第2期171-174,共4页中国化学快报（英文版）

基　　金：grant(No.F/2624-3F) from the International Foundation for Science(Sweden)

摘　　要：A new friedelane-type triterpene named 3β-hydroxyfriedelane-7,12,22-trione,as well as nine known compounds were isolated from the whole stems of Drypetes laciniata Hutch.（Euphorbiaceae）.Their structures were established on the basis of spectroscopic methods.The new triterpene derivative and a known saponin were tested for antimicrobial and antifungal activities and they appeared to be moderate active.A new friedelane-type triterpene named 3β-hydroxyfriedelane-7,12,22-trione,as well as nine known compounds were isolated from the whole stems of Drypetes laciniata Hutch.（Euphorbiaceae）.Their structures were established on the basis of spectroscopic methods.The new triterpene derivative and a known saponin were tested for antimicrobial and antifungal activities and they appeared to be moderate active.

关 键 词：Drypetes laciniata EUPHORBIACEAE STEM Friedelane-type triterpenoid Antimicrobial activity 

分 类 号：R285[医药卫生—中药学]