Lignan glucoside from Sinopodophyllum emodi and its cytotoxic activity  

作　　者：Chang Qi Zhao Yan Yan Zhu Shu Ying Chen Yukio Ogihara 

机构地区：[1]Beijing Key Lab of Gene Engineering Drugs & Biological Technology,Key Lab for Cell Proliferation & Regulation Biology of Ministry of Education,College of Life Sciences,Beijing Normal University,Beijing 100875,China [2]Faculty of Agronome and Biotechnology,Yunnan Agriculture University,Kunming 650201,China [3]Faculty of Pharmaceutical Sciences,Nagoya City University,Nagoya 467-8603,Japan

出　　处：《Chinese Chemical Letters》2011年第2期181-184,共4页中国化学快报（英文版）

基　　金：supported by the Chinese National Natural Science Foundation(No.30973869);the Ministry of Science and Technology of China(No.2008BAC39B05);Foundation of Shannxi Provincial Education Department

摘　　要：A new lignan glycoside was isolated from the n-butanol extract of the roots and rhizomes of Sinopodophyllum emodi.On the basis of spectral evidences,its structure was established and named as 4,5-didemethylpodophyllotoxin 7＇-O-β-D-glucopyranoside. This compound showed cytotoxicity against four human cancer cell lines（Hela,K562,SH-SY5Y and CNE） in vitro.A new lignan glycoside was isolated from the n-butanol extract of the roots and rhizomes of Sinopodophyllum emodi.On the basis of spectral evidences,its structure was established and named as 4,5-didemethylpodophyllotoxin 7＇-O-β-D-glucopyranoside. This compound showed cytotoxicity against four human cancer cell lines（Hela,K562,SH-SY5Y and CNE） in vitro.

关 键 词：Sinopodophyllum emodi BERBERIDACEAE 4 5-Didemethylpodophyllotoxin 7＇-O-β-D-glucopyranoside CYTOTOXICITY 

分 类 号：TQ464.2[化学工程—制药化工] TQ464.1