β-catenin、GSK3β在食管癌中的表达及其与食管癌浸润和转移的关系  

Expression ofβ-catenin,GSK3βin Esophageal Cancer and Its Correlation with Infiltration and Metastasis of Esophageal Cancer

作　　者：陈靖[1] 张京霞[1] 赵晓军[1] 刘淑霞[2] 张欣[2] 

机构地区：[1]石家庄市第二医院,石家庄050051 [2]河北医科大学,石家庄050000

出　　处：《中国医药导刊》2011年第1期104-106,共3页Chinese Journal of Medicinal Guide

基　　金：河北省医学科学研究重点课题计划(项目编号:08425)

摘　　要：目的:探讨β-catenin、GSK3β蛋白在食管癌组织中的表达变化,并分析其与病理学分级、浸润深度和淋巴结转移的关系。方法:应用免疫组织化学(IHC)SP法检测45例食管鳞状细胞癌组织及15例食管正常粘膜组织中β-catenin、GSK3β的表达。结果:β-catenin在癌组织中的阳性表达率明显高于正常组织(P<0.05);与淋巴结转移呈正相关(P<0.05)。GSK3β在癌组织中的阳性表达率明显低于正常组织(P<0.05);并与浸润深度(P<0.05)和淋巴结转移有关(P<0.05)。食管鳞状细胞癌中β-catenin蛋白与GSK3β蛋白的表达呈显著负相关(P<0.05)。结论:综合检测β-catenin和GSK3β对探讨食管鳞状细胞癌分化浸润转移和评估预后具有一定参考价值。Objective： To investigate the correlation of protein expression level of β-catenin, GSK3β with infiltration and metastasis in esophageal cancer tissues.Methods： The protein expression level of β-catenin and GSK3β was detected by immunohistochemistry （IHC） with Streptavidin-Peroxidase （SP） in 45 case of esophageal squamous cell carcinoma （ESCC） and 15 case of normal oesophagus tissues. Results： the result showed that the positive expression rate of β-catenin protein in carcinoma was higher than that in normal tissues （P〈0.05）. The expression of β-catenin was correlated with cell differential degree （P〈0.05）, lymph node memtastasis （P〈0.05）. the result showed that the positive expression rate of GSK3βin carcinoma was lower than that in normal tissues （P〈0.05）. The expression of GSK3β was correlated with fibromembranous invasion （P〈0.05） and lymph node memtastasis （P〈0.05）. There was a negative correlation between the expression of β-catenin and GSK3β protein in the esophageal carcinoma tissues （P〈0.05）.Condusion： Immunohistochemical detection of β-catenin and GSK3β expression may carry clinical significance inevaluating the degree of differentiation,invasiveness,metastaticpotential and prognosis of esophageal carcinoma.

关 键 词：食管鳞状细胞癌 Β-CATENIN GSK3Β 浸润 转移 

分 类 号：R735.1[医药卫生—肿瘤]