Design, Synthesis and Biological Evaluation of 2-Aroyl-3-aryl-6,7-dihydro-5H-furo[3,2-g]chromen Derivatives as a Novel Series of Estrogen Receptor Modulators  

作　　者：WANG Shi-hui WANG Yan ZHU Yu-ying LIU Si-jie HAN Jian ZHOU Yi-fan LI Da-wei KOIRALA Diwa HU Chun 

机构地区：[1]Key Laboratory of Structure-based Drug Design ＆ Discovery, Ministry of Education, Department of Organic Chemistry, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China [2]School of Pharmacy, Shanghai Jiaotong University, Shanghai 200193, P. R. China

出　　处：《Chemical Research in Chinese Universities》2011年第1期54-59,共6页高等学校化学研究（英文版）

基　　金：Supported by the National Natural Science Foundation of China(No20474053)

摘　　要：Based on the principles of the bioisosterism, combination of the active substructures of selective estrogen receptor modulators which are currently therapeutic agents available for the prevention and treatment of various estrogen dependent diseases, and structural optimization, a novel series of 2-aroyl-3-aryl-6,7-dihydro-5H-furo[3,2-g]- chromen derivatives was designed as potent selective estrogen receptor modulators via molecular docking. The target compounds have been synthesized, and characterized by 1R, proton NMR, ESI-MS, elemental analysis and evaluated for their antitumor activity against human osteosarcoma U2OS-EGFP-4FI2G cell line. Some target compounds showed good inhibition effects on U2OS-EGFP-4F12G cell line and the preliminary structure-activity relationships were discussed.Based on the principles of the bioisosterism, combination of the active substructures of selective estrogen receptor modulators which are currently therapeutic agents available for the prevention and treatment of various estrogen dependent diseases, and structural optimization, a novel series of 2-aroyl-3-aryl-6,7-dihydro-5H-furo[3,2-g]- chromen derivatives was designed as potent selective estrogen receptor modulators via molecular docking. The target compounds have been synthesized, and characterized by 1R, proton NMR, ESI-MS, elemental analysis and evaluated for their antitumor activity against human osteosarcoma U2OS-EGFP-4FI2G cell line. Some target compounds showed good inhibition effects on U2OS-EGFP-4F12G cell line and the preliminary structure-activity relationships were discussed.

关 键 词：Selective estrogen receptor modulator DOCKING Biological activity HETEROCYCLE Furo[3 2-g]chromen 

分 类 号：TQ457[化学工程—农药化工] Q579.13[生物学—生物化学]