GSTP1、E-cadherin在垂体腺瘤中的表达及临床意义  

Expressions of GSTP1 and E-cadherin in Pituitary Adenomas and Their Clinical Features

作　　者：刘健[1] 丁永忠[2] 李强[2] 任军[2] 张海林[2] 

机构地区：[1]兰州大学第二临床医学院,甘肃兰州730030 [2]兰州大学第二医院神经外科,甘肃兰州730030

出　　处：《现代生物医学进展》2011年第1期118-123,共6页Progress in Modern Biomedicine

基　　金：兰州大学医学科研基金项目(LZUYX200735)

摘　　要：目的:研究谷胱甘肽S-转移酶P1(GSTP1)、上皮钙粘蛋白(E-cadherin)在垂体腺瘤中的表达及临床意义。方法:应用免疫组化SP染色法检测30例侵袭性垂体腺瘤与30例非侵袭性垂体腺瘤中GSTP1、E-cadherin的表达。结果:GSTP1在侵袭性垂体腺瘤中的表达较非侵袭性垂体腺瘤显著降低(P<0.05);E-cadherin在侵袭性垂体腺瘤中的表达较非侵袭性垂体腺瘤显著降低(P<0.05);GSTP1、E-cadherin在垂体腺瘤中的表达呈正相关(r=0.82,P<0.05)。结论:GSTP1、E-cadherin在垂体腺瘤中的表达与肿瘤侵袭程度显著相关,两者联合检测有助于判断垂体腺瘤侵袭性及预后。Objective： To investigate the expressions of Glutathione S-transferases P1（GSTP1） and E-cadherin in pituitary adenomas and analyze their clinical significance.Methods： The SP immunohistochemical method was used to detect the expressions of GSTP1 and E-cadherin in 30 invasive pituitary adenomas and 30 noninvasive pituitary adenomas.Results： Expression of GSTP1 was significantly lower in invasive pituitary adenomas than in noninvasive pituitary adenomas（P0.05）;expression of E-cadherin protein was significantly lower in invasive pituitary adenomas than in noninvasive pituitary adenomas（P0.05）;expression of GSTP1 has positive correlation with the expression of E-cadherin in pituitary adenomas（r=0.82,P0.05）.Conclusions： The expressions of GSTP1 and E-cadherin are closely correlated with aggressive pituitary adenoma behavior,which are helpful for the evaluation of tumor invasion and prognosis.

关 键 词：垂体腺瘤 谷胱甘肽S-转移酶P1 上皮钙粘蛋白 免疫组织化学 

分 类 号：R739.4[医药卫生—肿瘤]