~1H NMR Investigation of Supramolecular Complex between β-Cyclodextrin and Cholesterol  

作　　者：JIANG Huiming ZHANG Shufen SHI Qi JIA Ying 

机构地区：[1]State Key Laboratory of Fine Chemicals, Dalian Universityof Technology, Dalian 116012, China [2]College of Life Science, Dalian Nationalities University,Dalian, 116600, China

出　　处：《Wuhan University Journal of Natural Sciences》2011年第1期79-82,共4页武汉大学学报（自然科学英文版）

基　　金：Supported by Autonomous Research Foundation (DC10040106);Central University Special Research Foundation

摘　　要：A supramolecular complex between β-cyclodextrin and cholesterol was synthesized and characterized via proton 1H NMR spectroscopy. In the supramolecular complex,the stoichiometric proportion of β-cyclodextrin to cholesterol is 1：2. The possible conformation of the supramolecular complex was depicted according to the chemical shift variance of proton 1H NMR of the host and guest molecules inside the inclusion complex. Removal efficiency of cholesterol complexed by β-cyclodextrin in our work is increased to a remarkable extent. This result can be applied in the field of drug development to reduce cholesterol in blood and other human organs.A supramolecular complex between β-cyclodextrin and cholesterol was synthesized and characterized via proton 1H NMR spectroscopy. In the supramolecular complex,the stoichiometric proportion of β-cyclodextrin to cholesterol is 1：2. The possible conformation of the supramolecular complex was depicted according to the chemical shift variance of proton 1H NMR of the host and guest molecules inside the inclusion complex. Removal efficiency of cholesterol complexed by β-cyclodextrin in our work is increased to a remarkable extent. This result can be applied in the field of drug development to reduce cholesterol in blood and other human organs.

关 键 词：supramolecular complex β-cyclodextrin （β-CD） 1H NMR CHOLESTEROL CONFORMATION 

分 类 号：O636.1[理学—高分子化学]