基于磁共振鼻咽癌咽旁间隙侵犯与预后关系的探讨  

Prognostic Influence of Parapharyngeal Space Involvement in Nasopharyngeal Carcinoma Based on MRI

作　　者：李娟[1] 莫浩元[1] 麦海强[1] 莫运仙[1] 邱慧芝[1] 郭翔[1] 

机构地区：[1]华南肿瘤学国家重点实验室中山大学肿瘤防治中心,广东广州510060

出　　处：《肿瘤学杂志》2011年第1期12-15,共4页Journal of Chinese Oncology

摘　　要：[目的]探讨基于磁共振鼻咽癌咽旁间隙受侵对预后的影响。[方法]185例M0期鼻咽癌患者,按咽旁间隙的侵犯程度进行划分,无咽旁侵犯记为0级,有咽旁侵犯而无颈动脉鞘区侵犯记为1级,有颈动脉鞘区侵犯记为2级。Kaplan-Meier法计算生存率,Cox模型进行预后多因素分析。[结果]咽旁间隙受侵与颅底骨质破坏有明显相关性(r=0.15,P=0.041)。多因素分析显示咽旁受侵不是独立的预后因素,但颈动脉鞘区受侵是影响鼻咽癌总生存、无远处转移的独立预后因素。[结论]单纯的咽旁受侵不影响预后,颈动脉鞘区受侵是独立预后因素。[Purpose] To investigate the prognostic influence of parapharyngeal space involvement in nasopharyngeal carcinoma based on magnetic resonance imaging （MRI）. [Methods] One hundred and eighty-five cases with nasopharyngeal carcinoma M0 stage, tumor extension to parapharyngeal space was staged according to the degree of the parapharyngeal space extension： patients without parapharyngeal involvement recorded as grade 0, with parapharyngeal involvement but without area of carotid sheath invasion recorded as grade 1, with area of carotid sheath invasion recorded as grade 2. The survival was calculated by Kaplan-Meier method, prognostic factor was analyzed by Cox multivariate model. [Results] Parapharyngeal space involvement was significantly associated with marrow invasion （r=0.15, P=0.041）. Multivariate analysis showed parapharyngeal involvement was not an independent prognostic factor, but the area of carotid sheath invasion was an independent prognostic factor which affected overall survival and distant metastasis. [Conclusion] Parapharyngeal involvement alone does not affect the prognosis, and the area of carotid sheath invasion is an independent prognostic factor.

关 键 词：鼻咽肿瘤 咽旁间隙 颈动脉鞘区 侵犯 预后 

分 类 号：R739.63[医药卫生—肿瘤]