调强放疗联合不同时间化疗对鼻咽癌患者腮腺功能影响  

The Efficacy of IMRT Combined with Chemotherapy at Various Time Points on Parotid Function in Patients with Nasopharyngeal Carcinoma

作　　者：张帆[1] 杨林[1] 洪浩[1] 汪志[1] 

机构地区：[1]安徽医科大学第一附属医院,安徽合肥230022

出　　处：《肿瘤学杂志》2011年第1期27-29,共3页Journal of Chinese Oncology

摘　　要：[目的]探讨调强放疗联合不同时间化疗对鼻咽癌患者腮腺功能的影响。[方法]初治鼻咽鳞癌患者39例,均无腮腺病史,随机分为单放组(单纯调强放射治疗)、放化组1(放疗第1周配合化疗)和放化组2(放疗第三周配合化疗)3组,每组13例。全组患者均采用全靶区调强放射治疗,化疗采用顺铂+多西紫杉醇。[结果]与单放组相比,放化组肿瘤局部控制率提高,但腮腺损伤加重,且放化组1对腮腺损伤更重。[结论]选择恰当时间放化治疗结合,可提高疗效,减少腮腺组织损伤。[Purpose] To investigate the effect of IMRT combined with chemotherapy at various time points on parotid function in patients with nasopharyngeal carcinoma.[Methods] Thirty-nine cases with nasopharyngeal squamous carcinoma were randomly divided into IMRT alone group,chemoradiotherapy group 1（chemotherapy begun at the first week of radiotherapy）and chemoradiotherapy group 2（chemotherapy begun at the third week of radiotherapy）;there were 13 patients in each group.All patients were treated with IMRT.Chemotherapy agents were cisplatin and paclitaxel.[Results] Compared with IMRT alone group,the local tumor control rate was higher in chemoradiotherapy group,but the injury of parotid gland was more serious,especially in chemoradiotherapy group 1.[Conclusions] Chemotherapy plus radiotherapy at various time points can improve therapeutic efficacy and reduce injury of parotid gland in patients with nasopharyngeal carcinoma.

关 键 词：鼻咽肿瘤 放射疗法 药物疗法 腮腺 

分 类 号：R739.63[医药卫生—肿瘤]