肝硬化患者血浆氧化型低密度脂蛋白测定  

Determination of Plasma Ox-LDL in patients with liver Cirrhosis

作　　者：卿笃信[1] 林礼茂[1] 凌奇荷[1] 

机构地区：[1]湖南医科大学附属第二医院消化内科,410011

出　　处：《临床肝胆病杂志》1999年第4期243-245,共3页Journal of Clinical Hepatology

摘　　要：本研究应用酶联免疫吸附法对肝硬化患者血浆氧化型低密度脂蛋白（Ｏｘ － ＬＤＬ） 进行测定。结果表明：正常对照组，肝硬化代偿期组和肝硬化失代偿期组血清Ｏｘ － ＬＤＬ 分别为（４２０ ．７±１１２ ．１）μｇ／Ｌ、（６３４ ．１ ±１６７ ．３）μｇ／Ｌ和（７１６ ．３ ±２５９．５）μｇ／Ｌ，后两组与正常对照组比较差异均有显著性（ Ｐ＜ ０ ．０１） 。肝硬化失代偿期患者Ｏｘ － ＬＤＬ与ＡＬＴ 及胆红素呈正相关（ Ｐ＜ ０．０５）与白蛋白呈负相关（ Ｐ＜ ０ ．０５） 。结果提示Ｏｘ － ＬＤＬ 是肝硬化发展过程中至肝损害的因素之一。Ｏｘ－ ＬＤＬ测定对肝硬化的病情判断有一定意义。Oxidized low density lipoprotein(Ox-LDL) was mesured by ELISA in 41 patients with cirrhosis and 16 healthy controls.The results showed that the plasma Ox-LDL were 420.7±112.1μg/L in healthy controls,634.1±167.3μg/L in compensation cirrhosis and 716.1±259.5 μg/L in uncompensation cirrhosis.The Ox-LDL of the two cirrhosis groups were higher than that of control (P<0.01).The pasitive correlation between the level of Ox-LDL and the level of ALT and bilirubin was observed (P<0.05).Negative correlation between the level of Ox-LDL and the level of albumin was observed (P<0.05).The results suggest that the Ox-LDL might play as an in jury factor in the pathogenesis of cirrhosis.The measurement of Ox-LDL should be useful in the assessment of severity for cirrhosis.

关 键 词：肝硬化 测定 OX-LDL ELISA 

分 类 号：R575.2[医药卫生—消化系统]