抑郁症患者脑脊液生长抑素及单胺代谢产物的测定  

Measurement of cerebrospinal fluid levels of somatostatin and monoamine metabolites in patients with depression

作　　者：陈珏[1] 张心保[1] 侯钢[1] 张石宁[1] 许瑞杰 翟书涛[1] 

机构地区：[1]南京医科大学附属脑科医院,210029 [2]南京军区总医院

出　　处：《中华精神科杂志》1999年第4期216-219,共4页Chinese Journal of Psychiatry

摘　　要：目的　探讨抑郁症可能的生化病理机制。方法　采用放射免疫测定法及高效液相色谱法，分别测定２７ 例抑郁症患者和２７ 例对照者脑脊液（ＣＳＦ）生长抑素（ＳＳ） 及单胺代谢产物水平。结果抑郁症组ＣＳＦ中ＳＳ水平和３甲氧４ 羟苯乙二醇（ＭＨＰＧ） 水平（ Ｐ＜ ０－０５） 和５羟吲哚乙酸水平（ Ｐ＜０－０１） 均低于对照组，而抑郁症组ＣＳＦ中高香草酸含量与对照组间的差异无显著性（ Ｐ＞０－０５） ；抑郁症组ＣＳＦ中ＳＳ与ＭＨＰＧ水平之间呈显著正相关（ｒ＝ ０－５９８ ，Ｐ＜ ０－０１） ； 抑郁症组ＣＳＦ中ＳＳ和ＭＨＰＧ 均与抑郁严重度呈负相关（ 前者ｒ＝ － ０－４７９ ，Ｐ＜ ０－０５ ；后者ｒ＝ － ０－４３４，Ｐ＜ ０－０５）。结论　抑郁症发病与单胺递质５羟色胺。Objective The aim of this study was to explore the possible pathophysiological mechanism in depression Methods Cerebrospinal fluid (CSF)somatostatin (SS) level was determined with radioimmunoassay, and CSF levels of monoamine metabolites were determined with high performance liquid chromatography in 27 patients with endogenous depression and 27 normal controls Results CSF levels of SS, 3 methoxy 4 hydroxyphenylglycol (MHPG) and 5 hydroxyindoleacetic acid were significantly lower in depressive group than in control group And in depressive group, a positive relationship was observed between CSF SS level and MHPG level ( r = 0 598, P< 0 01) CSF levels of both SS and MHPG in depression were significantly and negatively correlated with the depressive severity ( r= -0 479, P< 0 05; r= -0 434, P< 0 05) Conclusions Both monoamine neurotransmitters including serotonin (5 HT) and norepinephrine, and the neuropeptide SS might play important role in the pathophysiological mechanism of depression

关 键 词：抑郁症 生长抑素 MHPG 脑脊液 

分 类 号：R749.402[医药卫生—神经病学与精神病学]