奈莫必利与氟哌啶醇治疗精神分裂症的对照研究  

Comparison of nemonapride (emilace) to haloperidol in the treatment of schizophrenia

作　　者：黄淑贞[1] 姜佐宁[1] 秦英绂[1] 侯也之[1] 江伦 郭俊花[1] 王建勤[1] 史金玲 王玉华 周宝林 刘连清 刘正印 贺佳丽[1] 王秀玲 陈建生[1] 盛利霞[1] 

机构地区：[1]首都医科大学附属北京安定医院,100088

出　　处：《中华精神科杂志》1999年第4期226-229,共4页Chinese Journal of Psychiatry

摘　　要：目的　评价奈莫必利治疗精神分裂症的临床疗效和副反应。方法　对１３０ 例精神分裂症患者，应用奈莫必利（６７ 例） 与氟哌啶醇（６３ 例） 进行对照治疗，疗程８ 周。采用简明精神病量表（ＢＰＲＳ） 、阴性症状量表（ＳＡＮＳ）、临床总体印象量表（ＣＧＩ） 及副反应量表（ＴＥＳＳ）评定疗效和副反应。结果　奈莫必利与氟哌啶醇的疗效相似（ Ｐ＞０－０５）。奈莫必利与氟哌啶醇的显效率和有效率差异无显著性（ Ｐ＞０－０５）。治疗第６ 周末ＢＰＲＳ量表的活力缺乏因子减分率两组差异有显著性（ Ｐ＜ ０－０５）。ＳＡＮＳ量表的“语量缺乏”和“娱乐的兴致和活动减少”两项的改善率两药差异有显著性（ Ｐ＜０－０５） 。副反应两药相似，奈莫必利的主要副反应为震颤、静坐不能、肌强直、口干和便秘。结论　奈莫必利治疗精神分裂症有效，副反应与氟哌啶醇相似。奈莫必利可能更适用于慢性或以阴性症状为主的精神分裂症。Objective The aim of this study was to investigate the efficacy and safety of nemonapride in the treatment of schizophrenia Methods A total of 130 inpatients who met CCMD 2 R criteria for schizophrenia were randomly assigned to treatment with nemonapride ( n =67) or haloperidol ( n =63) for 8 weeks The efficacy was measured with the Brief Psychiatric Rating Scale (BPRS), the Scale for Assessment of Negative Symptoms (SANS), and the Clinical Global Impressions (CGI) The adverse events were determined by the Treatment Emergent Symptoms Scale (TESS) Results There was no significant difference between two groups in overall response rate showed by the reduction rate of BPRS total scores However, a significantly higher efficacy was demonstrated in nemonapride group than in haloperidol group in some negative symptoms, such as “adynamia” of BPRS subscale, and “lack of vocal inflections” or “decreased recreational interests and activities” of the SANS The overall incidence and presentations of the adverse events were comparable between two groups The most commonly observed treatment emergent adverse events of the patients with nemonapride treatment were tremor, akathisia, rigidity, dry mouth and constipation Conclusions It is suggested that both nemonapride and haloperidol are safe and effective in the management of schizophrenic symptoms Nemonapride appears to be more effective in treatment of some negative symptoms of schizophrenic patients than haloperidol

关 键 词：精神分裂症 氟哌啶醇 奈莫必利 治疗 

分 类 号：R749.3[医药卫生—神经病学与精神病学]