COX-2与VEGF在非霍奇金淋巴瘤中的表达及临床意义  

Expression of COX-2 and VEGF in non-hodgkin lymphoma and its clinical significance

作　　者：孙艳[1,2] 初晓霞[1] 于国华[3] 姜蕾[3] 

机构地区：[1]烟台毓璜顶医院血液科,山东省烟台264003 [2]滨州医学院 [3]山东省烟台毓璜顶医院病理科

出　　处：《中国医师杂志》2010年第12期1623-1627,共5页Journal of Chinese Physician

摘　　要：目的 探讨COX-2和VEGF在非霍奇金淋巴瘤（NHL）中的表达及临床意义.方法 采用免疫组化SP法检测COX-2和VEGF在42例NHL和20例良性淋巴结病变组织中的表达.结果 COX-2和VEGF在NHL中的阳性表达率分别为45.24%（19/42）和73.81%（31/42）.COX-2和VEGF在NHL的表达呈正相关（x2=4.63,P＜0.05）.COX-2的表达与NHL的临床分期和病理组织学类型具有相关性,Ⅲ/Ⅳ期NHL患者COX-2蛋白的表达明显高于Ⅰ/Ⅱ期患者（x2=5.43,P＜0.05）,侵袭性NHL患者COX-2蛋白的表达高于惰性组（x2=5.54,P＜0.05）,而与患者性别、年龄、全身症状、IPI无相关性.VEGF的表达与淋巴瘤侵袭性及全身症状、IPI显著相关（x2=8.98,8.89,6.43,P＜0.05）,而与患者的年龄、性别、临床分期均无相关性.结论 COX-2、VEGF可能参与NHL的发生、发展过程,COX-2可能通过上调VEGF促进NHL组织的血管新生.选择性COX-2抑制剂可望成为NHL治疗的新靶点.Objectiye To explore the expression of COX-2 and VEGF and its clinical significance in non-Hodgkin lymphoma （NHL）. Methods The expression of COX-2 and VEGF were detected by immunohistochemistry in 42 cases of NHL and 20 cases of lymph node with benign pathological change. Results The positive rate of COX-2 and VEGF was 45.24% and 73.81% in NHL respectively. The expression rate of VEGF was positively correlated with that of COX-2 in tissues of NHL （ x2 = 4. 63, P ＜ 0. 05）.The expression of COX-2 was related to clinical stage and histopathologic grade of NHL （ x2 = 5.43, P ＜0. 05）, but it had no association with gender, age, B symptoms, and IPI. The expression of VEGF was significantly related with aggression, B symptoms and IPI （ x2 =8. 979, 8. 893,6. 434, P ＜0. 05）, but it had no association with age, gender and clinical stages. Conclusion COX-2 and VEGF may be involved in NHL tumorgenesis, and COX-2 may accelerate angiogenesis by increasing VEGF expression. Specific COX-2 inhibitors may be a novel therapeutic approach for NHL.

关 键 词：前列腺素内过氧化物合酶类/代谢 血管内皮生长因子类/代谢 淋巴瘤 非霍奇金/代谢 

分 类 号：R733.1[医药卫生—肿瘤]