尿路移行细胞癌雌孕激素受体的免疫组化研究  

STUDY OF ER AND PR IN HUMAN TRANSITIONAL CELL CARCINOMA OF URINARY TRACT WITH IMMUNOHISTOCHEMISTRY

作　　者：李凤歧[1] 马建国[1] 李哲[1] 王寿祥[1] 李向东[1] 苗文隆[1] 薄爱华[2] 戴洁[2] 

机构地区：[1]张家口医学院一附院,o07500 [2]张家口医学院电镜室,075000

出　　处：《张家口医学院学报》1999年第1期23-24,共2页

摘　　要：为探讨雌激素受体(ER)、孕激素受体(PR)在尿路移行细胞癌中的表达及生物学意义,对64例尿路移行细胞癌石蜡标本进行了免疫组化(SABC法)检测。结果是示:ER、PR阳性率分别为53.1％和50.0％;其中在高分化癌中ER、PR表达高于低分化癌;分级间比较有显著性差异(P<0.05);ER、PR阳性率随肿瘤分期升高而下降,但分期间比较无显著性差异(P>0.05);另外单发肿瘤、多发肿瘤及复发肿瘤之间,男女两性肿瘤之间及尿路各部位之间,ER、PR阳性表达率亦无显著性差异。结论:尿路移行细胞癌ER、PR有较高的表达率.且和分级正相关,提示ER、PR表达可能对尿路移行细胞癌有某种直接或间接的影响,并可作为肿瘤愈后判断指标之一。Estrogen and progesterone recepters were investigated with immmunohistochemstry(SABC).Result showed that ER and PR were found positive in 34)53.1 %)and 32)50.0 %)respectively.Rate of ER and PR in cell were related with grading of carcinoma cell(P<0.05),but were not related with staging,sex,type and sites of tumors(P>0.05).The result demonstrated that ER and PR may serve as a useful marker of transitional cell carcinoma of urinary tract.

关 键 词：移行细胞癌 ER PR 免疫组织化学 尿路移行细胞癌 

分 类 号：R737.03[医药卫生—肿瘤]