Cx26与胃癌预后的关系  

THE RELATIONSHIP BETWEEN Cx26 AND PROGNOSIS OF GASTRIC CANCER

作　　者：林林[1] 蔡建辉[1] 阎庆辉[1] 任鹏涛[1] 

机构地区：[1]河北医科大学第二医院胃肠外科,河北石家庄050000

出　　处：《河北医科大学学报》2011年第1期27-30,共4页Journal of Hebei Medical University

摘　　要：目的研究细胞间隙连接蛋白26(connexin 26,Cx26)表达与胃癌临床病理特点及预后间的关系。方法治疗性切除患者84例,组织样本经Cx26抗体免疫组织化学染色后的表达情况及与病理分型的相关性。并与正常组织做对照。结果胃癌患者中Cx26阳性表达率为54.8%,Cx26表达与生存、病理分型有相关性(P<0.05),Cx26表达阳性的肿瘤患者比Cx26表达阴性的肿瘤患者有更长的生存时间。Kaplan-Meier生存分析显示,Cx26表达是一个独立预后因素。结论在胃癌切除术后患者中,Cx26表达是一个独立预后因素。Objective To investigate the correlation between connexin 26 （Cx26） expression and the clinicopathological features of gastric cancer. Methods Eighty - four patients who underwent a curative resection were studied. Tissue samples were detected by immunohistochemical staining using antibodies for Cx26. Moreover, investigated the survival rate of all of the patients. Results Cx26 expression was found in 46 cases （54.8%）. A correlation was observed between the Cx26 expression and survival, pathological type （ P 〈 0.05 ）. Cx26 positive tumors had significantly longer survival than Cx26 negative tumors （ P 〈 0.05）. Kaplan - Meier analysis demonstrated that Cx26 expression was an independent prognostic factor. Conclusion This study suggests that Cx26 expression is an independent prognostic factor in patients that undergo a curative resection of gastric cancer.

关 键 词：连接蛋白26 胃肿瘤 预后 

分 类 号：R735.2[医药卫生—肿瘤]