CCND1基因G870A多态性与肺癌危险性的Meta分析  

The association study between the CCND1 G870A polymorphism and the risk of lung cancer: a meta-analysis

作　　者：朱陵君[1] 朱全[1] 张锦英[1] 刘连科[1] 郭人花[1] 李俊[1] 束永前[1] 

机构地区：[1]江苏省南京医科大学第一附属医院,江苏南京210029

出　　处：《实用临床医药杂志》2011年第3期18-20,23,共4页Journal of Clinical Medicine in Practice

基　　金：江苏省博士后基金资助项目(2010)

摘　　要：目的研究细胞周期素D1（Cyclin D1,CCND1）基因G870A多态性与肺癌（Lung cancer）危险性的关系。方法检索中国医学文献数据库和PubMed,获取所有关于CCND1基因G870A与肺癌危险性的病例-对照研究,使用Meta分析方法合并G870A与肺癌危险性关系的OR值。同时进行异质性分析、亚组分析和发表偏倚检验。采用固定效应模型和随机效应模型进行分析。结果纳入符合标准的文献有8篇,共包括4 747例病例和4 512例对照,在显性模型下,G870A多态性能够增加罹患肺癌的风险（OR=1.12,95%CI=1.02~1.23）。种族分层分析发现,此危险在高加索人群中更为显著,而在亚洲人群中并未显著。结论 CCND1基因G870A多态性是肺癌的易感性位点,而且在高加索人群中更为显著。Objective To explore the association between the cyclin D1（CCND1） G870A polymorphism and lung cancer susceptibility.Methods CMB databases and PubMed were searched to get all the case-control studies on the association between the G870A polymorphism and lung cancer risk.In addition,OR with the association was from the Meta-analysis.Heterogeneity,stratified analysis,and publication bias test were assessed in the meta-analysis.Using fixed model or random model to analyze the results.Results A total of eight eligible studies with 4,747 lung cancer cases and 4,512 control subjects were included in this study.The G870A polymorphism was associated with lung caner risk in the dominant model（OR=1.12,95%CI=1.02～1.23）,and this increased risk was more pronounced among Caucasians.Conclusion The CCND1 G870A polymorphism may contribute to lung cancer risk,especially among Caucasians.

关 键 词：CCND1 肺癌 META分析 

分 类 号：R734.2[医药卫生—肿瘤]