血清同型半胱氨酸与小儿特发性癫痫的相关性研究  

Study on the correlation between serum homocysteine levels with pediatric idiopathic epilepsy

作　　者：刘云[1] 王利军[2] 韩明清[3] 

机构地区：[1]滨州市人民医院小儿科,山东省滨州256610 [2]滨州市人民医院输血科,山东省滨州256610 [3]滨州市人民医院妇科,山东省滨州256610

出　　处：《中国基层医药》2011年第4期468-470,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨血清同型半胱氨酸（Hcy）与小儿特发性癫痫的相关性。方法将81例小儿特发性癫痫患儿（研究组）的血清Hey水平与48例健康儿童（对照组）进行对比分析。结果研究组81例癫痫患儿的Hcy水平为7．6—22．0μmol／L，平均（15．91±2．38）μmol／L，而对照组48例健康儿童的Hcy水平为3—9μmol／L，平均（6．87±1．75）μmol／L。两组间差异有统计学意义（P〈0．05）。对照组小儿仅有6例Hcy水平高于15μmol／L，而研究组中有73例Hcy水平高于15μmol／L，差异有统计学意义（P〈0．05）。同时全身强直．阵挛性发作和简单或复杂性部分性发作两种癫痫之间的Hey水平差异无统计学意义（P〉0．05）。结论小儿特发性癫痫与高Hey血症存在显著关系，在对小儿特发性癫痫患临床治疗时，应密切监控患儿的血清Hcy水平，及时促进Hcy体内代谢。Objective To study the clinical significance of determination on homocysteine in serum of pediatric idiopathic epilepsy. Methods The homoeysteine level in serum of 81 patients with pediatric idiopathic epilepsy was determined, and the value of normal children was tested and compared as control. Results The concentration of Hey in research group was from 7.6μmol/L to 22. 0μmol/L,the mean value was（ 15.91 ± 2.38）μmol/L, The concentration of Hey in control group was from 3μmol/L to 9μmol/L,and the mean value was（6.87 ±1.75）μmol/L. which showed a significant difference（ P 〈 0.05 ）. By comparison, the high concentration （ 〉 15μmol/L） of Hey in control group was only 6 cases, while it was 73 cases in research group, which also showed a significant difference （ P 〈 0.05 ）. Conclusion Hey level was apparently relevant with occurring rate of pediatric idiopathic epilepsy. In the diagnosed clinical treatment of idiopathic epilepsy, the closely monitor of serum level of homoeysteine, and timely promoting Hey metabolism, should be carried out.

关 键 词：同型半胱氨酸 小儿 特发性 癫痫 

分 类 号：R742[医药卫生—神经病学与精神病学]