重组组织型纤溶酶原激活剂静脉溶栓治疗急性脑梗死患者对血清白介素-17的影响  

rt-PA thrombolysis for acute cerebral infarction patients serum interleukin-17

作　　者：邵可可[1] 荣良群[2] 魏秀娥[2] 

机构地区：[1]徐州医学院神经病学教研室,江苏徐州221000 [2]徐州医学院第二附属医院神经内科

出　　处：《中华脑血管病杂志（电子版）》2011年第1期27-29,共3页Chinese Journal of Cerebrovascular Diseases(Electronic Edition)

摘　　要：目的观察重组组织型纤溶酶原激活剂(rt-PA)溶栓治疗对急性脑梗死患者血清白介素-17(IL-17)的影响,探讨IL-17在脑梗死发病机制中的作用。方法 采用酶联免疫吸附法(ELISA)检测急性脑梗死患者rt-PA溶栓治疗前后血清IL-17浓度值,并与常规治疗组、正常对照组比较。结果 两治疗组治疗前血清IL-17浓度明显高于对照组(P<0.001)。治疗前及治疗后12h,溶栓组和常规治疗组血清IL-17浓度无明显差异(P>0.05)。治疗后12h溶栓组血清IL-17浓度明显下降(P<0.001),而常规治疗组IL-17浓度继续增高,3d后血清IL-17浓度下降(P<0.05)。治疗14d溶栓组血清IL-17浓度与对照组无明显差异(P>0.05),常规治疗组则明显高于对照组(P<0.001)。结论 急性脑梗死患者血清IL-17水平明显升高,rt-PA溶栓治疗能显著降低急性脑梗死患者血清IL-17的水平。Objective To observe the level of interleukin-17 （IL-17）in serum in those patients whom injuried by acute cerebral infarction treated by recombinant tissue-type plasminogen activator（ rt-PA）, and to identify the role of IL-17 in the pathogenesis of cerebral infarction. Methods Using enzyme-linked immunosorbent method（ELISA） detect the level of IL-17 in serum of those patients who suffer acute cerebral infarction before and after using rt-PA respectively, and compared to regular treatment group and conventional control. Results Before treatment,the level of IL-17 in serum in the two treatment groups were significantly higher than those in the conventional control（ P 〈 0.001 ）. Before and after treatment within 12h, the level of IL-17 in serum was not significant different between the thrombolysis group and the regular treatment group （P 〉 0.05 ）. 12h after using rt-PA, the level of IL-17 in serum of the thrombolysis group declined （P 〈 0.001 ）, While the level of IL-17 in serum of the regular treatment group continue to increase, 3 days later, the level of IL-17 in serum began to decline （P 〈0.05）. After 14 days＇ treatment,the level of IL-17 in serum is not significant different between the thrombolysis group and the conventional control （ P 〉 0.05 ）, the level of IL-17 in serum of the regular treatment group is obviously higher than that in the conventional control （ P 〈 0.001 ）. Conclusions The level of IL-17 in serum of these patients who are suffering acute cerebral infarc- tion increased significantly,the treatment of rt-PA can reduce the level of IL-17 of these patients significantly. So we can find a new way to treat these patients who are suffering acute cerebral infarction to intervene the inflammatory mediators of IL-17.

关 键 词：急性脑梗死 重组组织型纤溶酶原激活剂 白细胞介素-17 

分 类 号：R743.3[医药卫生—神经病学与精神病学]