石杉碱甲联合尼莫地平治疗血管性痴呆的对照观察  

Comparison Observation of Huperzine A Conbined With Nimodipine in the Treatment of Vascular Dementia

作　　者：王群松[1] 于海燕[1] 季莉[1] 袁周玲 袁菁[1] 

机构地区：[1]中国.江苏省无锡市精神卫生中心,214151

出　　处：《中国健康心理学杂志》2011年第2期154-155,共2页China Journal of Health Psychology

摘　　要：目的观察石杉碱甲联合尼莫地平治疗轻、中度血管性痴呆（VD）的临床疗效和安全性。方法 64例轻、中度VD患者随机分为两组。治疗组32例,服用石杉碱甲100ug,2次/日,尼莫地平30mg,3次/日。对照组32例,服用石杉碱甲100ug,2次/日。两组总疗程为12周。采用简易精神状态检查表（MMSE）、日常生活能力量表（ADL）作为评价指标。结果石杉碱甲联合尼莫地平治疗12周后MMSE、ADL分数分别较对照组明显改善（23.25±2.71,25.39±5.37,P〈0.01）。结论石杉碱甲联合尼莫地平治疗血管性痴呆（VD）较单用石杉碱甲可显著改善VD患者的认知功能,且安全性良好。Objective To observe the efficacy and safety of Huperzine A conbined with Nimodipine in treating the mild to moderate vascular dementia（VD）.Methods A total of 64 cases of patients with the mild to moderate VD were randomly divided into 2 groups.The treated group with 32 cases were treated with huperzine A capsule 100 ug,po,bid and Nimodipine 30mg,po,tid.The control group with 32 cases were treated with Huperzine A capsule 100 ug,po,bid.The whole course of treatment for each group was 12 weeks.Minimental State Examination（MMSE） and Activit of Daily Livings Scale（ADL） were taken as the main value indicators.Results After 12 weeks,the marks of MMSE and ADL of the treatment group were more improved than those of the control group（23.25±2.71,25.39±5.37,P0.01）.Conclusion Huperzine A conbined with Nimodipine can prominently improve the cognitive function of patients with the mild to moderate vascular dementia.Morever,its security and tolerability is good.

关 键 词：石杉碱甲 尼莫地平 血管性痴呆 

分 类 号：R749.13[医药卫生—神经病学与精神病学]