调节性T细胞与肝细胞肝癌免疫的研究进展  

Research progress of regulatory T Cells in hepatocellular carcinoma immunity

作　　者：樊永丽[1] 任秀宝[1] 

机构地区：[1]天津市肿瘤防治重点实验室天津医科大学附属肿瘤医院生物治疗科,300070

出　　处：《国际免疫学杂志》2011年第2期127-130,共4页International Journal of Immunology

摘　　要：调节性T细胞（Treg）是一类具有独特免疫调节功能的T细胞亚群，可通过多种方式抑制肿瘤免疫，在肿瘤的发生、发展过程中发挥着极为重要的作用。随着对Treg研究的不断深入，越来越多的证据表明Treg通过多种机制参与了肝癌特别是肝细胞肝癌的形成和发展，减少Treg数量能够增强患者的抗肿瘤免疫功能，是肝细胞肝癌预后的独立危险因子；反之，肝癌局部微环境的一些细胞因子能够影响Treg的表型，增强其抑制功能。As a functionally unique subset of T cells, regulatory T cells （Treg） suppress tumor immune responses effectively through a variety of mechanisms and play an important role in tumorigenesis and tumor progression. With the deepening research of Treg, There is growing evidence suggests that Treg participate in the formation and development of hepatic tumor, especially hepatocellular carcinoma（HCC）. Decreasing the number of Treg could strengthen the antitumor immunity. There fore, the number of Trcg is an independent risk factor for HCC prognosis. On the contrary, some cytokines in hepatic tumor microenvironment can affect the phenotype of Treg and enhance their suppressive function.

关 键 词：调节性T细胞 肝细胞肝癌 免疫抑制 免疫治疗 

分 类 号：R735.7[医药卫生—肿瘤]