甘氨酸螯合铁纳米脂质体对缺铁性贫血大鼠的补铁效果  

Effectiveness of Treatment of Iron-Deficiency Anemia in Rats with Ferrous Glycinate Nanoliposomes

作　　者：丁保淼[2] 张晓鸣[1,2] 夏书芹[2] 

机构地区：[1]食品科学与技术国家重点实验室,江南大学,江苏无锡214122 [2]江南大学食品学院,江苏无锡214122

出　　处：《食品与生物技术学报》2011年第1期49-54,共6页Journal of Food Science and Biotechnology

基　　金：国家863计划项目(2007AA100403);江苏省科技支撑计划项目(BE2008326)

摘　　要：研究了甘氨酸螯合铁纳米脂质体作为补铁剂对缺铁性贫血大鼠的补铁效果。通过对SD品系初断乳大鼠喂养缺铁基础饲料,建立缺铁性贫血大鼠模型,再用甘氨酸螯合铁纳米脂质体对缺铁性贫血大鼠补铁,并与甘氨酸螯合铁和硫酸亚铁进行比较。结果表明,甘氨酸螯合铁纳米脂质体能够显著增加大鼠血液中血红蛋白含量,提高血清铁含量,降低血清总铁结合力(P<0.05);并且它能够有效地促进大鼠肝脾组织中铁含量的增加。因而,甘氨酸螯合铁纳米脂质体可显著改善大鼠的缺铁性贫血状况,且比甘氨酸螯合铁和硫酸亚铁有更好的补铁效果。The effect of ferrous glycinate nanoliposomes on iron-deficiency anemia was investigated through comparing with that of ferrous glycinate and ferrous sulfate on SD rats.. Hb, serum Fe, total iron binding capacity, iron contents of liver and spleen were determined at the end of the intervention, and significant effects were observed for Hb, serum Fe, total iron binding capacity, and iron contents of liver and spleen （P〈 0. 05） in ferrous glycinate nanoliposomes group. Ferrous glycinate nanoliposomes as an iron supplement performed better than ferrous glycinate and ferrous sulfate in groups of iron-deficient rats.

关 键 词：甘氨酸螯合铁纳米脂质体 缺铁性贫血 大鼠 补铁 

分 类 号：R556[医药卫生—血液循环系统疾病]