利培酮合并西酞普兰及认知疗法治疗强迫症的观察  

Observation on Risperidone Combined with Citalopram and Cognitive Therapy in Treatment of Obsessive-compulsive Disorder

作　　者：田志林[1] 李秀珊[1] 张丽娜[1] 沈振明[1] 孙淑红[1] 张竹[1] 

机构地区：[1]中国河北省唐山市第五医院,063000

出　　处：《中国健康心理学杂志》2011年第1期10-11,共2页China Journal of Health Psychology

摘　　要：目的观察利培酮合并西酞普兰及认知行为疗法治疗强迫症的疗效和不良反应。方法将84例强迫症患者随机平分为两组,治疗组以利培酮合并西酞普兰及认知行为治疗,对照组以西酞普兰合并认知行为治疗,疗程12周,以强迫症量表(Y-BOCS)、汉密尔顿焦虑量表(HAM A)评定疗效,以副反应量表(TESS)评定不良反应。结果利培酮合并西酞普兰及认知疗法组显效率高于西酞普兰合并认知疗法组(Y-BOCS:t=2.76,P<0.05),12周末Y-BOCS、HAMA评分低于对照组。两组间TESS评分差异无显著性(P>0.05)。结论利培酮合并西酞普兰及认知疗法治疗强迫症安全有效。Objective To observe the curative effect and side raction of Risperidone combined with Citalopram and cognitive therapy in treatment of obsessive-compulsive disorder.Methods A total of 84 patients with obsessive-compulsive disorder were didided into two groups.The treatment group received Risperidone combined with Citalopram and cognitive therapy,the control group received Citalopram and the cognition behavior therapy,the treatment course was 12 weeks.The curative effects were evaluated by the obsession meter（Y-BOCS） and the Hamilton anxiety scale（HAMA）,the side ractions were evaluated by the side reaction meter（TESS）.Results The effective rate of the group treated by Risperidone combined with Citalopram and cognitive therapy were more efficient than the group treated by Citalopram combined with cognitive therapy（Y-BOCS：t=2.76,P〈0.05）,the scores of Y-BOCS and HAMA were lower than the control group at 12 weekend.TESS scores between the two groups showed no significant（P〉0.05）.Conclusion Risperidone combined with Citalopram and cognitive therapy is safe and effective in treatment of obsessive-compulsive disorder.

关 键 词：利培酮 西酞普兰 认知行为疗法 强迫症 

分 类 号：R749.94[医药卫生—神经病学与精神病学]