瓣状内切核酸酶1与肿瘤  

The relationship between FEN1 and tumor

作　　者：马进举[1] 陈彬[2] 卞士柱[1] 

机构地区：[1]第三军医大学学员旅1队,重庆400038 [2]第三军医大学生物化学与分子生物学教研室,重庆400038

出　　处：《生命的化学》2011年第1期36-40,共5页Chemistry of Life

基　　金：国家自然科学基金(30972933);重庆市自然科学基金(CSTC.2009AC5173);第三军医大学归国人员启动基金(2009)资助

摘　　要：瓣状内切核酸酶1(flap endonuclease 1,FEN1)是一种结构特异性核酸酶,由一个核心结构域和一条尾链组成。FEN1在DNA修复过程中冈崎片段成熟时RNA引物的切除,长片段碱基切除修复中瓣状结构的切除等过程中发挥着重要作用。FEN1与不同的蛋白质相互作用,在不同的DNA复制和修复途径中发挥着重要作用。FEN1在肿瘤中有着异常的表达,这表明它可能是一种潜在的肿瘤标记物。Flap endonuclease-1 （FEN1） is a structure-specific nuclease, which consists of the nuclease core domain and the C-terminal tail. FEN1 plays a crucial role in the removal of RNA primers during Okazaki fragment maturation in DNA repair process and the efficient removal of 5-flaps during long-patch base excision repair. In the different DNA replication and repair pathways, FEN1 has an important role through interaction with different proteins. It has been found to be abnormally expressed in various tumors, suggesting that it may be a potential tumor marker.

关 键 词：瓣状内切核酸酶1 DNA修复 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]