构建分子标记连锁图谱的图论构图方法  

Graphic Theoretical Method for Mapping Molecular Marker Loci

作　　者：谭远德[1] 万春玲[2] 周泽阳 鲁成[3] 向仲怀[3] 

机构地区：[1]湖南师范大学生命科学学院,长沙410081 [2]南京师范大学生命科学学院,南京210097 [3]农业部蚕桑重点开放实验室

出　　处：《生物数学学报》1999年第3期338-347,共10页Journal of Biomathematics

基　　金：国家自然科学基金!(39870568);国家自然科学基金!(3970730)

摘　　要：结合统计学、遗传学和图论原理，建立了一种新的分子标记连锁图谱构建的方法，即图论构图法．应用这种方法，从７７个家蚕ＲＡＰＤ标记位点中构建了７个标记位点的两个连锁群．与ＭＡＰＭＡＲＫＥＲ程序所构建的结果相比表明，图论构图法具有更为可靠的构图效果．Construction of molecular marker-based linkage map has become one of the hot points in molecular biology. At the same time, statistic methods and softwares for mapping molecular marker loci have been developed. As a study of methodology, a new approach, graphic theoretcial method, was developed on the basis of combination of statistics, genetics and graphic theory in this paper. Two linkage groups including 7 RAPD loci were mapped from 77 RAPD markers in silkworm (Bombyxmori. L.) by our approach. As compared with the mapping these 77 RAPD markers by MAPMARKER program, the result shows that our approach of graphic theory is more confident in mapping molecular marker loci.

关 键 词：连锁图谱 分子标记 图论 连锁检测 

分 类 号：Q343.241[生物学—遗传学] O157.5[理学—数学]