p185蛋白及其抗体的研究进展  

Advances in Research of p185 Protein and Its Antibodies .

作　　者：王琛[1] 刘兢[1] 

机构地区：[1]中国科学技术大学生命科学学院,合肥230027

出　　处：《生物化学与生物物理进展》1999年第4期347-349,共3页Progress In Biochemistry and Biophysics

摘　　要：描述了ｐ１８５ 在信号转导过程中的功能， 讨论了抗ｐ１８５ 抗体的蛋白质工程及它们在肿瘤治疗中的应用．p185 neu/c erbB 2 is a receptor tyrosine kinase . Its overexpressed in some adenocarcinomas, such as breast cancer and ovary cancer. It not only plays an important prognostic role, but also acts as a therapeutic target in breast cancer. Its function in signal tranduction is described. The protein engineering of antibodies against p185 and their application in cancer therapy is also discussed.

关 键 词：信号转导 预后 肿瘤治疗 P185蛋白 抗体 

分 类 号：R73－36[医药卫生—肿瘤]